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Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy

The past decade has witnessed the explosive development of cancer immunotherapies. Nevertheless, low immunogenicity, limited specificity, poor delivery efficiency, and off‐target side effects remain to be the major limitations for broad implementation of cancer immunotherapies to patient bedside. En...

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Detalles Bibliográficos
Autores principales: Ruan, Shaobo, Huang, Yuanyu, He, Mei, Gao, Huile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165523/
https://www.ncbi.nlm.nih.gov/pubmed/35343112
http://dx.doi.org/10.1002/advs.202200027
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author Ruan, Shaobo
Huang, Yuanyu
He, Mei
Gao, Huile
author_facet Ruan, Shaobo
Huang, Yuanyu
He, Mei
Gao, Huile
author_sort Ruan, Shaobo
collection PubMed
description The past decade has witnessed the explosive development of cancer immunotherapies. Nevertheless, low immunogenicity, limited specificity, poor delivery efficiency, and off‐target side effects remain to be the major limitations for broad implementation of cancer immunotherapies to patient bedside. Encouragingly, advanced biomaterials offering cell‐specific modulation of immunological cues bring new solutions for improving the therapeutic efficacy while relieving side effect risks. In this review, focus is given on how functional biomaterials can enable cell‐specific modulation of cancer immunotherapy within the cancer‐immune cycle, with particular emphasis on antigen‐presenting cells (APCs), T cells, and tumor microenvironment (TME)‐resident cells. By reviewing the current progress in biomaterial‐based cancer immunotherapy, here the aim is to provide a better understanding of biomaterials’ role in targeting modulation of antitumor immunity step‐by‐step and guidelines for rationally developing targeting biomaterials for more personalized cancer immunotherapy. Moreover, the current challenge and future perspective regarding the potential application and clinical translation will also be discussed.
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spelling pubmed-91655232022-06-04 Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy Ruan, Shaobo Huang, Yuanyu He, Mei Gao, Huile Adv Sci (Weinh) Reviews The past decade has witnessed the explosive development of cancer immunotherapies. Nevertheless, low immunogenicity, limited specificity, poor delivery efficiency, and off‐target side effects remain to be the major limitations for broad implementation of cancer immunotherapies to patient bedside. Encouragingly, advanced biomaterials offering cell‐specific modulation of immunological cues bring new solutions for improving the therapeutic efficacy while relieving side effect risks. In this review, focus is given on how functional biomaterials can enable cell‐specific modulation of cancer immunotherapy within the cancer‐immune cycle, with particular emphasis on antigen‐presenting cells (APCs), T cells, and tumor microenvironment (TME)‐resident cells. By reviewing the current progress in biomaterial‐based cancer immunotherapy, here the aim is to provide a better understanding of biomaterials’ role in targeting modulation of antitumor immunity step‐by‐step and guidelines for rationally developing targeting biomaterials for more personalized cancer immunotherapy. Moreover, the current challenge and future perspective regarding the potential application and clinical translation will also be discussed. John Wiley and Sons Inc. 2022-03-27 /pmc/articles/PMC9165523/ /pubmed/35343112 http://dx.doi.org/10.1002/advs.202200027 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ruan, Shaobo
Huang, Yuanyu
He, Mei
Gao, Huile
Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title_full Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title_fullStr Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title_full_unstemmed Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title_short Advanced Biomaterials for Cell‐Specific Modulation and Restore of Cancer Immunotherapy
title_sort advanced biomaterials for cell‐specific modulation and restore of cancer immunotherapy
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165523/
https://www.ncbi.nlm.nih.gov/pubmed/35343112
http://dx.doi.org/10.1002/advs.202200027
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