Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease

BACKGROUND: Inflammatory bowel disease may arise with inadequate immune response to intestinal bacteria. NOD2 is an established gene in Crohn’s disease pathogenesis, with deleterious variation associated with reduced NFKB signaling. We hypothesized that deleterious variation across the NOD2 signalin...

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Detalles Bibliográficos
Autores principales: Ashton, James J, Boukas, Konstantinos, Stafford, Imogen S, Cheng, Guo, Haggarty, Rachel, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Williams, Anthony P, Polak, Marta E, Beattie, R Mark, Ennis, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic Science Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165556/
https://www.ncbi.nlm.nih.gov/pubmed/34978330
http://dx.doi.org/10.1093/ibd/izab318

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