New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease

The preset neurodegenerations in Alzheimer disease (AD) are due to several mechanisms such as amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, neurofibrillary tangles, cholinergic dysfunction, among others. The aim of this work was to develop multitarget molecules for the tre...

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Detalles Bibliográficos
Autores principales: García Marín, Iohanan Daniel, Camarillo López, Raúl Horacio, Martínez, Oscar Aurelio, Padilla-Martínez, Itzia Irene, Correa-Basurto, José, Rosales-Hernández, Martha Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165844/
https://www.ncbi.nlm.nih.gov/pubmed/35657793
http://dx.doi.org/10.1371/journal.pone.0269129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165844/
https://www.ncbi.nlm.nih.gov/pubmed/35657793
http://dx.doi.org/10.1371/journal.pone.0269129

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