Cargando…

New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease

The preset neurodegenerations in Alzheimer disease (AD) are due to several mechanisms such as amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, neurofibrillary tangles, cholinergic dysfunction, among others. The aim of this work was to develop multitarget molecules for the tre...

Descripción completa

Detalles Bibliográficos
Autores principales:	García Marín, Iohanan Daniel, Camarillo López, Raúl Horacio, Martínez, Oscar Aurelio, Padilla-Martínez, Itzia Irene, Correa-Basurto, José, Rosales-Hernández, Martha Cecilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165844/ https://www.ncbi.nlm.nih.gov/pubmed/35657793 http://dx.doi.org/10.1371/journal.pone.0269129

Ejemplares similares

Multitarget Approach to Drug Candidates against Alzheimer’s Disease Related to AChE, SERT, BACE1 and GSK3β Protein Targets
por: Ivanova, Larisa, et al.
Publicado: (2020)

Tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl)carbamate Has Moderated Protective Activity in Astrocytes Stimulated with Amyloid Beta 1-42 and in a Scopolamine Model
por: Camarillo-López, Raúl Horacio, et al.
Publicado: (2020)

N-Heterocycles Scaffolds as Quorum Sensing Inhibitors. Design, Synthesis, Biological and Docking Studies
por: Fuentes-Gutiérrez, Alfredo, et al.
Publicado: (2020)

Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity
por: Romero-Castro, Aurelio, et al.
Publicado: (2016)

Preclinical Pharmacokinetics and Acute Toxicity in Rats of 5-{[(2E)-3-Bromo-3-carboxyprop-2-enoyl]amino}-2-hydroxybenzoic Acid: A Novel 5-Aminosalicylic Acid Derivative with Potent Anti-Inflammatory Activity
por: Gutiérrez-Sánchez, Mara, et al.
Publicado: (2021)

Exposure to heterocyclic amines.
por: Wakabayashi, K, et al.
Publicado: (1993)

Autoxidation of Heterocyclic Aminals
por: Zhai, Feng, et al.
Publicado: (2017)

Molecular docking of fisetin with AD associated AChE, ABAD and BACE1 proteins
por: Dash, Raju, et al.
Publicado: (2014)

Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico
por: Macías-Pérez, Martha Edith, et al.
Publicado: (2013)

Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor
por: Andrade-Jorge, Erik, et al.
Publicado: (2018)

In Silico and In Vitro Studies of Benzothiazole-Isothioureas Derivatives as a Multitarget Compound for Alzheimer’s Disease
por: Rosales Hernández, Martha Cecilia, et al.
Publicado: (2022)

New Benzamides as Multi-Targeted Compounds: A Study on Synthesis, AChE and BACE1 Inhibitory Activity and Molecular Docking
por: Drozdowska, Danuta, et al.
Publicado: (2023)

Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors
por: González-Naranjo, Pedro, et al.
Publicado: (2022)

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo
por: Stern, Noa, et al.
Publicado: (2022)

Inhibitory effects of black cumin on the formation of heterocyclic aromatic amines in meatball
por: Oz, Emel
Publicado: (2019)

Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies
por: Gil-Edo, Raquel, et al.
Publicado: (2023)

Cytotoxic Action of Carboxyborane Heterocyclic Amine Adducts
por: Miller, Merrill C., et al.
Publicado: (1997)

Heterocyclic amines: occurrence and prevention in cooked food.
por: Robbana-Barnat, S, et al.
Publicado: (1996)

Mutagenic activity of heterocyclic amines in cooked foods.
por: Felton, J S, et al.
Publicado: (1994)

Immunoaffinity purification of dietary heterocyclic amine carcinogens.
por: Vanderlaan, M, et al.
Publicado: (1993)

Heterocyclic amines (HCAS) and risk of breast cancer
por: Sinha, R, et al.
Publicado: (2001)

Metabolism and biomarkers of heterocyclic aromatic amines in humans
por: Bellamri, Medjda, et al.
Publicado: (2021)

Myeloperoxidase Inhibitory and Antioxidant Activities of (E)-2-Hydroxy-α-aminocinnamic Acids Obtained through Microwave-Assisted Synthesis
por: Rivera-Antonio, Astrid, et al.
Publicado: (2021)

Baicalein as a Potential Inhibitor against BACE1 and AChE: Mechanistic Comprehension through In Vitro and Computational Approaches
por: Han, Jin, et al.
Publicado: (2019)

Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
por: Mathew, Bijo, et al.
Publicado: (2021)

1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors
por: Maliszewski, Dawid, et al.
Publicado: (2021)

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies
por: Martín-Beltrán, Celia, et al.
Publicado: (2021)

Fentanyl Structure as a Scaffold for Opioid/Non-Opioid Multitarget Analgesics
por: Lipiński, Piotr F. J., et al.
Publicado: (2022)

Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.
por: Ohgaki, H, et al.
Publicado: (1986)

Synthesis of hydrazides of heterocyclic amines and their antimicrobial and spasmolytic activity
por: Berillo, Dmitriy A., et al.
Publicado: (2022)

Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells
por: Méndez-Luna, David, et al.
Publicado: (2021)

Therapeutic potential of heterocyclic pyrimidine scaffolds
por: Kumar, Sanjiv, et al.
Publicado: (2018)

Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer’s Disease
por: Bao, Le-Quang, et al.
Publicado: (2023)

Chromoselective access to Z- or E- allylated amines and heterocycles by a photocatalytic allylation reaction
por: Martínez-Gualda, Ana María, et al.
Publicado: (2019)

Heterocyclic amine-induced cancer and myocardial lesions in nonhuman primates.
por: Felton, J S
Publicado: (1994)

Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides
por: Su, Mingjuan, et al.
Publicado: (2014)

Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer’s Disease
por: Wang, Nan, et al.
Publicado: (2022)

Heterocyclic Aromatic Amines in Meat: Formation, Isolation, Risk Assessment, and Inhibitory Effect of Plant Extracts
por: Nadeem, Hafiz Rehan, et al.
Publicado: (2021)

Inhibitory effect of acylated anthocyanins on heterocyclic amines in grilled chicken breast patty and its mechanism
por: Teng, Hui, et al.
Publicado: (2022)

Repurposing FDA Drug Compounds against Breast Cancer by Targeting EGFR/HER2
por: Balbuena-Rebolledo, Irving, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8i9q0p4375pv66h2sk4lh8co86