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Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166215/ https://www.ncbi.nlm.nih.gov/pubmed/35665869 http://dx.doi.org/10.1186/s43044-022-00284-8 |
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author | Umeh, Chukwuemeka A. Kumar, Sabina Wassel, Elias Barve, Pranav |
author_facet | Umeh, Chukwuemeka A. Kumar, Sabina Wassel, Elias Barve, Pranav |
author_sort | Umeh, Chukwuemeka A. |
collection | PubMed |
description | BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality in COVID-19 patients. This study aims to assess the relationship between bradycardia and mortality in COVID-19 patients by reviewing existing literature. MAIN BODY: Articles were obtained by systematically searching the PubMed and Google scholar databases. Qualitative and quantitative analyses of the studies on bradycardia and mortality in COVID-19 were done. A pooled estimate, with a sample size of 1320 patients, comparing the effect of patients that were bradycardic during their admission with those that were not on mortality showed that bradycardia did not lead to increased mortality in COVID-19 patients (OR 1.25, 95% CI 0.41–3.84, p = 0.7). CONCLUSIONS: This meta-analysis showed that bradycardia was not significantly associated with mortality in COVID-19 patients. However, this study is limited by the few studies on bradycardia and mortality in COVID-19 patients. Therefore, future studies should investigate this relationship so that clinicians can prognostically triage and treat COVID-19 patients appropriately. |
format | Online Article Text |
id | pubmed-9166215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-91662152022-06-07 Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality Umeh, Chukwuemeka A. Kumar, Sabina Wassel, Elias Barve, Pranav Egypt Heart J Review BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality in COVID-19 patients. This study aims to assess the relationship between bradycardia and mortality in COVID-19 patients by reviewing existing literature. MAIN BODY: Articles were obtained by systematically searching the PubMed and Google scholar databases. Qualitative and quantitative analyses of the studies on bradycardia and mortality in COVID-19 were done. A pooled estimate, with a sample size of 1320 patients, comparing the effect of patients that were bradycardic during their admission with those that were not on mortality showed that bradycardia did not lead to increased mortality in COVID-19 patients (OR 1.25, 95% CI 0.41–3.84, p = 0.7). CONCLUSIONS: This meta-analysis showed that bradycardia was not significantly associated with mortality in COVID-19 patients. However, this study is limited by the few studies on bradycardia and mortality in COVID-19 patients. Therefore, future studies should investigate this relationship so that clinicians can prognostically triage and treat COVID-19 patients appropriately. Springer Berlin Heidelberg 2022-06-04 /pmc/articles/PMC9166215/ /pubmed/35665869 http://dx.doi.org/10.1186/s43044-022-00284-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Umeh, Chukwuemeka A. Kumar, Sabina Wassel, Elias Barve, Pranav Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title | Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title_full | Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title_fullStr | Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title_full_unstemmed | Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title_short | Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality |
title_sort | meta-analysis and systematic literature review of covid-19 associated bradycardia as a predictor of mortality |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166215/ https://www.ncbi.nlm.nih.gov/pubmed/35665869 http://dx.doi.org/10.1186/s43044-022-00284-8 |
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