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Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality

BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality...

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Autores principales: Umeh, Chukwuemeka A., Kumar, Sabina, Wassel, Elias, Barve, Pranav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166215/
https://www.ncbi.nlm.nih.gov/pubmed/35665869
http://dx.doi.org/10.1186/s43044-022-00284-8
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author Umeh, Chukwuemeka A.
Kumar, Sabina
Wassel, Elias
Barve, Pranav
author_facet Umeh, Chukwuemeka A.
Kumar, Sabina
Wassel, Elias
Barve, Pranav
author_sort Umeh, Chukwuemeka A.
collection PubMed
description BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality in COVID-19 patients. This study aims to assess the relationship between bradycardia and mortality in COVID-19 patients by reviewing existing literature. MAIN BODY: Articles were obtained by systematically searching the PubMed and Google scholar databases. Qualitative and quantitative analyses of the studies on bradycardia and mortality in COVID-19 were done. A pooled estimate, with a sample size of 1320 patients, comparing the effect of patients that were bradycardic during their admission with those that were not on mortality showed that bradycardia did not lead to increased mortality in COVID-19 patients (OR 1.25, 95% CI 0.41–3.84, p = 0.7). CONCLUSIONS: This meta-analysis showed that bradycardia was not significantly associated with mortality in COVID-19 patients. However, this study is limited by the few studies on bradycardia and mortality in COVID-19 patients. Therefore, future studies should investigate this relationship so that clinicians can prognostically triage and treat COVID-19 patients appropriately.
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spelling pubmed-91662152022-06-07 Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality Umeh, Chukwuemeka A. Kumar, Sabina Wassel, Elias Barve, Pranav Egypt Heart J Review BACKGROUND: Cardiac arrhythmias have been identified as independent predictors of mortality in Coronavirus disease 2019 (COVID-19) patients. While some studies have reported poor prognosis with bradycardia in COVID-19 patients, others have not found any association between bradycardia and mortality in COVID-19 patients. This study aims to assess the relationship between bradycardia and mortality in COVID-19 patients by reviewing existing literature. MAIN BODY: Articles were obtained by systematically searching the PubMed and Google scholar databases. Qualitative and quantitative analyses of the studies on bradycardia and mortality in COVID-19 were done. A pooled estimate, with a sample size of 1320 patients, comparing the effect of patients that were bradycardic during their admission with those that were not on mortality showed that bradycardia did not lead to increased mortality in COVID-19 patients (OR 1.25, 95% CI 0.41–3.84, p = 0.7). CONCLUSIONS: This meta-analysis showed that bradycardia was not significantly associated with mortality in COVID-19 patients. However, this study is limited by the few studies on bradycardia and mortality in COVID-19 patients. Therefore, future studies should investigate this relationship so that clinicians can prognostically triage and treat COVID-19 patients appropriately. Springer Berlin Heidelberg 2022-06-04 /pmc/articles/PMC9166215/ /pubmed/35665869 http://dx.doi.org/10.1186/s43044-022-00284-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Umeh, Chukwuemeka A.
Kumar, Sabina
Wassel, Elias
Barve, Pranav
Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title_full Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title_fullStr Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title_full_unstemmed Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title_short Meta-analysis and systematic literature review of COVID-19 associated bradycardia as a predictor of mortality
title_sort meta-analysis and systematic literature review of covid-19 associated bradycardia as a predictor of mortality
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166215/
https://www.ncbi.nlm.nih.gov/pubmed/35665869
http://dx.doi.org/10.1186/s43044-022-00284-8
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