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Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia

OBJECTIVE: To study cardiovascular events and clinical outcomes in patients with elevated glycated hemoglobin (HbA1c) levels and/or admission hyperglycemia and those with type 2 diabetes hospitalized with SARS-CoV-2 pneumonia. METHODS: This was a multicenter retrospective study of 1645 patients hosp...

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Autores principales: Krishnasamy, Sathya, Sheikh, Daniya, Ali, T’shura, Clemons, Victoria, Furmanek, Stephen, Mohamed Fawzy Abdelhaleem, Ahmed Abdelhaleem, Salunkhe, Vidyulata, Akbar, Usman Ali, Chlebowy, Diane, Ramirez, Julio, Arnold, Forest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AACE. Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166248/
https://www.ncbi.nlm.nih.gov/pubmed/35671878
http://dx.doi.org/10.1016/j.eprac.2022.05.011
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author Krishnasamy, Sathya
Sheikh, Daniya
Ali, T’shura
Clemons, Victoria
Furmanek, Stephen
Mohamed Fawzy Abdelhaleem, Ahmed Abdelhaleem
Salunkhe, Vidyulata
Akbar, Usman Ali
Chlebowy, Diane
Ramirez, Julio
Arnold, Forest
author_facet Krishnasamy, Sathya
Sheikh, Daniya
Ali, T’shura
Clemons, Victoria
Furmanek, Stephen
Mohamed Fawzy Abdelhaleem, Ahmed Abdelhaleem
Salunkhe, Vidyulata
Akbar, Usman Ali
Chlebowy, Diane
Ramirez, Julio
Arnold, Forest
author_sort Krishnasamy, Sathya
collection PubMed
description OBJECTIVE: To study cardiovascular events and clinical outcomes in patients with elevated glycated hemoglobin (HbA1c) levels and/or admission hyperglycemia and those with type 2 diabetes hospitalized with SARS-CoV-2 pneumonia. METHODS: This was a multicenter retrospective study of 1645 patients hospitalized with SARS-CoV-2 pneumonia. Diagnosis of SARS-CoV-2 pneumonia required a positive reverse transcription-polymerase chain reaction result for SARS-CoV-2, presence of new or worsening pulmonary infiltrates on computed tomography scan or chest x-ray, and at least one of following: (1) new or increased cough, (2) temperature of >37.8 °C, or (3) dyspnea. Outcomes included in-hospital cardiovascular events, intensive care unit admission, and mortality. Logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for association of elevated HbA1c levels and/or admission hyperglycemia and type 2 diabetes for individual outcomes. RESULTS: Among 1645 adults hospitalized with SARS-CoV-2 pneumonia, 18 with type 1 diabetes were excluded from the analysis. Of 1627 adults, 634 (39%) had known diagnosis of type 2 diabetes, and among 993 patients with no diabetes, 107 (10.8%) patients were identified with elevated HbA1c levels and/or admission hyperglycemia. Patients with elevated HbA1c levels and/or admission hyperglycemia had increased odds of developing acute in-hospital cardiovascular events (OR, 1.73; 95% CI, 1.07-2.80), intensive care unit admissions (OR, 1.61; 95% CI, 1.10-2.34), and mortality (OR, 1.77; 95% CI, 1.02-3.07) compared to patients with type 2 diabetes and no diabetes. CONCLUSION: Patients with elevated HbA1c levels and/or admission hyperglycemia hospitalized with SARS-CoV-2 pneumonia have increased risk of developing acute in-hospital cardiovascular complications and overall poor clinical outcomes compared with patients with type 2 diabetes and no diabetes.
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spelling pubmed-91662482022-06-07 Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia Krishnasamy, Sathya Sheikh, Daniya Ali, T’shura Clemons, Victoria Furmanek, Stephen Mohamed Fawzy Abdelhaleem, Ahmed Abdelhaleem Salunkhe, Vidyulata Akbar, Usman Ali Chlebowy, Diane Ramirez, Julio Arnold, Forest Endocr Pract Original Article OBJECTIVE: To study cardiovascular events and clinical outcomes in patients with elevated glycated hemoglobin (HbA1c) levels and/or admission hyperglycemia and those with type 2 diabetes hospitalized with SARS-CoV-2 pneumonia. METHODS: This was a multicenter retrospective study of 1645 patients hospitalized with SARS-CoV-2 pneumonia. Diagnosis of SARS-CoV-2 pneumonia required a positive reverse transcription-polymerase chain reaction result for SARS-CoV-2, presence of new or worsening pulmonary infiltrates on computed tomography scan or chest x-ray, and at least one of following: (1) new or increased cough, (2) temperature of >37.8 °C, or (3) dyspnea. Outcomes included in-hospital cardiovascular events, intensive care unit admission, and mortality. Logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for association of elevated HbA1c levels and/or admission hyperglycemia and type 2 diabetes for individual outcomes. RESULTS: Among 1645 adults hospitalized with SARS-CoV-2 pneumonia, 18 with type 1 diabetes were excluded from the analysis. Of 1627 adults, 634 (39%) had known diagnosis of type 2 diabetes, and among 993 patients with no diabetes, 107 (10.8%) patients were identified with elevated HbA1c levels and/or admission hyperglycemia. Patients with elevated HbA1c levels and/or admission hyperglycemia had increased odds of developing acute in-hospital cardiovascular events (OR, 1.73; 95% CI, 1.07-2.80), intensive care unit admissions (OR, 1.61; 95% CI, 1.10-2.34), and mortality (OR, 1.77; 95% CI, 1.02-3.07) compared to patients with type 2 diabetes and no diabetes. CONCLUSION: Patients with elevated HbA1c levels and/or admission hyperglycemia hospitalized with SARS-CoV-2 pneumonia have increased risk of developing acute in-hospital cardiovascular complications and overall poor clinical outcomes compared with patients with type 2 diabetes and no diabetes. AACE. Published by Elsevier Inc. 2022-08 2022-06-04 /pmc/articles/PMC9166248/ /pubmed/35671878 http://dx.doi.org/10.1016/j.eprac.2022.05.011 Text en © 2022 AACE. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Krishnasamy, Sathya
Sheikh, Daniya
Ali, T’shura
Clemons, Victoria
Furmanek, Stephen
Mohamed Fawzy Abdelhaleem, Ahmed Abdelhaleem
Salunkhe, Vidyulata
Akbar, Usman Ali
Chlebowy, Diane
Ramirez, Julio
Arnold, Forest
Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title_full Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title_fullStr Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title_full_unstemmed Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title_short Impact of Hyperglycemia on Cardiovascular Events and Clinical Outcomes in Patients Hospitalized With COVID-19 Pneumonia
title_sort impact of hyperglycemia on cardiovascular events and clinical outcomes in patients hospitalized with covid-19 pneumonia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166248/
https://www.ncbi.nlm.nih.gov/pubmed/35671878
http://dx.doi.org/10.1016/j.eprac.2022.05.011
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