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Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models. Yet, in patients the two structural genetic ab...

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Detalles Bibliográficos
Autores principales:	Manceau, Line, Richard Albert, Julien, Lollini, Pier-Luigi, Greenberg, Maxim V. C., Gilardi-Hebenstreit, Pascale, Ribes, Vanessa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166405/ https://www.ncbi.nlm.nih.gov/pubmed/35604932 http://dx.doi.org/10.1371/journal.pgen.1009782

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