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The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe?
Background: Lactose intolerance (LI) appears usually in later ages when the lactase enzyme becomes deficient or absent in the small intestine. Conflicting results have been reported in the literature about the association of lactose intolerance with various gastrointestinal malignancies. Hence, our...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166465/ https://www.ncbi.nlm.nih.gov/pubmed/35676992 http://dx.doi.org/10.7759/cureus.24713 |
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author | Asfari, Mohammad Maysara Hamid, Osama Sarmini, Muhammad Talal Kendrick, Katherine Pappoppula, Lakshmi Priyanka Sifuentes, Humberto Sridhar, Subbaramiah |
author_facet | Asfari, Mohammad Maysara Hamid, Osama Sarmini, Muhammad Talal Kendrick, Katherine Pappoppula, Lakshmi Priyanka Sifuentes, Humberto Sridhar, Subbaramiah |
author_sort | Asfari, Mohammad Maysara |
collection | PubMed |
description | Background: Lactose intolerance (LI) appears usually in later ages when the lactase enzyme becomes deficient or absent in the small intestine. Conflicting results have been reported in the literature about the association of lactose intolerance with various gastrointestinal malignancies. Hence, our aim was to study the association between LI, colon cancer (CCa), and gastric cancer (GC) using a large database. Methods: A cross-sectional study was performed using the National Inpatient Sample (NIS) database between 2004 and 2014. We identified adult patients (18-90 years) who were diagnosed with LI (study group) using appropriate International Classification of Diseases, Ninth Revision (ICD-9) codes. The control group comprised patients who did not have a diagnosis of LI. We identified the diagnosis of CCa and GC in both study and control groups using the ICD-9 codes. Univariable and multivariable logistic regression analyses were performed to assess the association between LI, CCa, and GC. Results: The total population comprised 71,360,501 patients, of which 57,909 (0.08%) were diagnosed with LI. LI patients were older (62 vs 51 years) with more females (61.5% vs 60.1%) and less African American patients (11.8% vs 14.3%) (p <0.0001 for all). In addition, LI patients had more smoking (12.4% vs 12%) and obesity (15% vs 8.9%). On the other hand, patients in the LI group had less alcohol use (3.8% vs 4.2%) (p <0.0001). After adjusting for the age, gender, race, smoking, alcohol, obesity, and inflammatory bowel disease, the LI group had a slightly lower rate of CCa (OR 0 .974, 95%CI 0.906-1.048, p = 0.486) and a lower rate of GC (OR: 0.993, 95%CI 0.924-1.068, p =0.853); however, the results were not statistically significant. Conclusion: Patients with lactose intolerance may have a lower risk of colon and gastric cancer. However, these findings were not statistically significant. Further studies are needed to understand this association. |
format | Online Article Text |
id | pubmed-9166465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-91664652022-06-07 The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? Asfari, Mohammad Maysara Hamid, Osama Sarmini, Muhammad Talal Kendrick, Katherine Pappoppula, Lakshmi Priyanka Sifuentes, Humberto Sridhar, Subbaramiah Cureus Gastroenterology Background: Lactose intolerance (LI) appears usually in later ages when the lactase enzyme becomes deficient or absent in the small intestine. Conflicting results have been reported in the literature about the association of lactose intolerance with various gastrointestinal malignancies. Hence, our aim was to study the association between LI, colon cancer (CCa), and gastric cancer (GC) using a large database. Methods: A cross-sectional study was performed using the National Inpatient Sample (NIS) database between 2004 and 2014. We identified adult patients (18-90 years) who were diagnosed with LI (study group) using appropriate International Classification of Diseases, Ninth Revision (ICD-9) codes. The control group comprised patients who did not have a diagnosis of LI. We identified the diagnosis of CCa and GC in both study and control groups using the ICD-9 codes. Univariable and multivariable logistic regression analyses were performed to assess the association between LI, CCa, and GC. Results: The total population comprised 71,360,501 patients, of which 57,909 (0.08%) were diagnosed with LI. LI patients were older (62 vs 51 years) with more females (61.5% vs 60.1%) and less African American patients (11.8% vs 14.3%) (p <0.0001 for all). In addition, LI patients had more smoking (12.4% vs 12%) and obesity (15% vs 8.9%). On the other hand, patients in the LI group had less alcohol use (3.8% vs 4.2%) (p <0.0001). After adjusting for the age, gender, race, smoking, alcohol, obesity, and inflammatory bowel disease, the LI group had a slightly lower rate of CCa (OR 0 .974, 95%CI 0.906-1.048, p = 0.486) and a lower rate of GC (OR: 0.993, 95%CI 0.924-1.068, p =0.853); however, the results were not statistically significant. Conclusion: Patients with lactose intolerance may have a lower risk of colon and gastric cancer. However, these findings were not statistically significant. Further studies are needed to understand this association. Cureus 2022-05-03 /pmc/articles/PMC9166465/ /pubmed/35676992 http://dx.doi.org/10.7759/cureus.24713 Text en Copyright © 2022, Asfari et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Gastroenterology Asfari, Mohammad Maysara Hamid, Osama Sarmini, Muhammad Talal Kendrick, Katherine Pappoppula, Lakshmi Priyanka Sifuentes, Humberto Sridhar, Subbaramiah The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title | The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title_full | The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title_fullStr | The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title_full_unstemmed | The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title_short | The Association of Lactose Intolerance With Colon and Gastric Cancers: Friend or Foe? |
title_sort | association of lactose intolerance with colon and gastric cancers: friend or foe? |
topic | Gastroenterology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166465/ https://www.ncbi.nlm.nih.gov/pubmed/35676992 http://dx.doi.org/10.7759/cureus.24713 |
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