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Acne Vulgaris and Metabolic Syndrome: A Possible Association

Introduction Acne vulgaris is an androgen-dependent disorder with excessive sebum production and proliferation of Propionibacterium acnes. Metabolic syndrome (MetS) is a multisystem disorder that increases the risk of diabetes mellitus, stroke, and cardiovascular diseases. ​This study aims to analyz...

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Autores principales: Chandak, Sejal, Singh, Adarshlata, Madke, Bhushan, Jawade, Sugat, Khandelwal, Rachit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166482/
https://www.ncbi.nlm.nih.gov/pubmed/35677010
http://dx.doi.org/10.7759/cureus.24750
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author Chandak, Sejal
Singh, Adarshlata
Madke, Bhushan
Jawade, Sugat
Khandelwal, Rachit
author_facet Chandak, Sejal
Singh, Adarshlata
Madke, Bhushan
Jawade, Sugat
Khandelwal, Rachit
author_sort Chandak, Sejal
collection PubMed
description Introduction Acne vulgaris is an androgen-dependent disorder with excessive sebum production and proliferation of Propionibacterium acnes. Metabolic syndrome (MetS) is a multisystem disorder that increases the risk of diabetes mellitus, stroke, and cardiovascular diseases. ​This study aims to analyze the association of MetS with acne vulgaris. Methods A cross-sectional study was conducted with 65 cases of acne vulgaris and 65 age and sex-matched controls. We used the system provided by the Indian authors for grading acne according to the clinical severity. In addition, the criteria updated according to the joint consensus of 2009 were employed for the diagnosis of MetS. Results On clinical examination, grade 2 was the most prevalent grade of acne. We observed an increased incidence of abnormal waist circumference, triglyceride, HDL, and fasting blood glucose among the cases (p<0.05). Consequently, an increased occurrence of MetS was observed in the case group (p=0.011). While comparing the mean values of the parameters, we noted a significant difference in terms of waist circumference and HDL values. An increased mean value of waist circumference was noted in the case group while an increased mean value of HDL was reported from the control group (p<0.05).  Conclusion Patients with acne vulgaris have a greater chance of developing MetS. Hence, an in-depth examination of clinical, anthropometric, and biochemical parameters that may lead to the development of MetS is necessary.
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spelling pubmed-91664822022-06-07 Acne Vulgaris and Metabolic Syndrome: A Possible Association Chandak, Sejal Singh, Adarshlata Madke, Bhushan Jawade, Sugat Khandelwal, Rachit Cureus Dermatology Introduction Acne vulgaris is an androgen-dependent disorder with excessive sebum production and proliferation of Propionibacterium acnes. Metabolic syndrome (MetS) is a multisystem disorder that increases the risk of diabetes mellitus, stroke, and cardiovascular diseases. ​This study aims to analyze the association of MetS with acne vulgaris. Methods A cross-sectional study was conducted with 65 cases of acne vulgaris and 65 age and sex-matched controls. We used the system provided by the Indian authors for grading acne according to the clinical severity. In addition, the criteria updated according to the joint consensus of 2009 were employed for the diagnosis of MetS. Results On clinical examination, grade 2 was the most prevalent grade of acne. We observed an increased incidence of abnormal waist circumference, triglyceride, HDL, and fasting blood glucose among the cases (p<0.05). Consequently, an increased occurrence of MetS was observed in the case group (p=0.011). While comparing the mean values of the parameters, we noted a significant difference in terms of waist circumference and HDL values. An increased mean value of waist circumference was noted in the case group while an increased mean value of HDL was reported from the control group (p<0.05).  Conclusion Patients with acne vulgaris have a greater chance of developing MetS. Hence, an in-depth examination of clinical, anthropometric, and biochemical parameters that may lead to the development of MetS is necessary. Cureus 2022-05-05 /pmc/articles/PMC9166482/ /pubmed/35677010 http://dx.doi.org/10.7759/cureus.24750 Text en Copyright © 2022, Chandak et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Chandak, Sejal
Singh, Adarshlata
Madke, Bhushan
Jawade, Sugat
Khandelwal, Rachit
Acne Vulgaris and Metabolic Syndrome: A Possible Association
title Acne Vulgaris and Metabolic Syndrome: A Possible Association
title_full Acne Vulgaris and Metabolic Syndrome: A Possible Association
title_fullStr Acne Vulgaris and Metabolic Syndrome: A Possible Association
title_full_unstemmed Acne Vulgaris and Metabolic Syndrome: A Possible Association
title_short Acne Vulgaris and Metabolic Syndrome: A Possible Association
title_sort acne vulgaris and metabolic syndrome: a possible association
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166482/
https://www.ncbi.nlm.nih.gov/pubmed/35677010
http://dx.doi.org/10.7759/cureus.24750
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