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Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients

BACKGROUND: Osteoarthritis (OA) is an age-related joint disease characterized by progressive cartilage loss. Synovial mesenchymal stem cells (MSCs) are anticipated as a cell source for OA treatment; however, synovial MSC preparations isolated from OA patients contain many senescent cells that inhibi...

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Detalles Bibliográficos
Autores principales:	Miura, Yugo, Endo, Kentaro, Komori, Keiichiro, Sekiya, Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166575/ https://www.ncbi.nlm.nih.gov/pubmed/35658936 http://dx.doi.org/10.1186/s13287-022-02901-4

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