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Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice
BACKGROUND: Liver fibrosis is an outcome of restoring process in chronic liver injury. Human amniotic mesenchymal stem cells (hAMSCs) derived from amniotic membrane have multilineage differentiation, immunosuppressive, and anti-inflammatory potential which makes them suitable for treating liver fibr...
Autores principales: | Liu, Quan-Wen, Ying, Yan-Min, Zhou, Jia-Xin, Zhang, Wen-Jie, Liu, Zhao-xiao, Jia, Bing-Bing, Gu, Hao-Cheng, Zhao, Chu-Yu, Guan, Xiao-Hui, Deng, Ke-Yu, Xin, Hong-Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166579/ https://www.ncbi.nlm.nih.gov/pubmed/35659360 http://dx.doi.org/10.1186/s13287-022-02906-z |
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