Concordance of hydrogen peroxide–induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors

Oxidative DNA damage has been linked to inflammation, cancer, and aging. Here, we have mapped two types of oxidative DNA damage, oxidized guanines produced by hydrogen peroxide and oxidized thymines created by potassium permanganate, at a single-base resolution. 8-Oxo-guanine occurs strictly depende...

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Detalles Bibliográficos
Autores principales: Jin, Seung-Gi, Meng, Yingying, Johnson, Jennifer, Szabó, Piroska E., Pfeifer, Gerd P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166614/
https://www.ncbi.nlm.nih.gov/pubmed/35658030
http://dx.doi.org/10.1126/sciadv.abn3815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166614/
https://www.ncbi.nlm.nih.gov/pubmed/35658030
http://dx.doi.org/10.1126/sciadv.abn3815

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