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Absolute optical chiral analysis using cavity-enhanced polarimetry

Chiral analysis is central for scientific advancement in the fields of chemistry, biology, and medicine. It is also indispensable in the development and quality control of chiral compounds in the chemical and pharmaceutical industries. Here, we present the concept of absolute optical chiral analysis...

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Detalles Bibliográficos
Autores principales: Bougas, Lykourgos, Byron, Joseph, Budker, Dmitry, Williams, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166628/
https://www.ncbi.nlm.nih.gov/pubmed/35658039
http://dx.doi.org/10.1126/sciadv.abm3749
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author Bougas, Lykourgos
Byron, Joseph
Budker, Dmitry
Williams, Jonathan
author_facet Bougas, Lykourgos
Byron, Joseph
Budker, Dmitry
Williams, Jonathan
author_sort Bougas, Lykourgos
collection PubMed
description Chiral analysis is central for scientific advancement in the fields of chemistry, biology, and medicine. It is also indispensable in the development and quality control of chiral compounds in the chemical and pharmaceutical industries. Here, we present the concept of absolute optical chiral analysis, as enabled by cavity-enhanced polarimetry, which allows for accurate unambiguous enantiomeric characterization and enantiomeric excess determination of chiral compounds within complex mixtures at trace levels, without the need for calibration, even in the gas phase. Our approach and technology enable the absolute postchromatographic chiral analysis of complex gaseous mixtures, the rapid quality control of complex mixtures containing chiral volatile compounds, and the online in situ observation of chiral volatile emissions from a plant under stress.
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spelling pubmed-91666282022-06-17 Absolute optical chiral analysis using cavity-enhanced polarimetry Bougas, Lykourgos Byron, Joseph Budker, Dmitry Williams, Jonathan Sci Adv Physical and Materials Sciences Chiral analysis is central for scientific advancement in the fields of chemistry, biology, and medicine. It is also indispensable in the development and quality control of chiral compounds in the chemical and pharmaceutical industries. Here, we present the concept of absolute optical chiral analysis, as enabled by cavity-enhanced polarimetry, which allows for accurate unambiguous enantiomeric characterization and enantiomeric excess determination of chiral compounds within complex mixtures at trace levels, without the need for calibration, even in the gas phase. Our approach and technology enable the absolute postchromatographic chiral analysis of complex gaseous mixtures, the rapid quality control of complex mixtures containing chiral volatile compounds, and the online in situ observation of chiral volatile emissions from a plant under stress. American Association for the Advancement of Science 2022-06-03 /pmc/articles/PMC9166628/ /pubmed/35658039 http://dx.doi.org/10.1126/sciadv.abm3749 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Bougas, Lykourgos
Byron, Joseph
Budker, Dmitry
Williams, Jonathan
Absolute optical chiral analysis using cavity-enhanced polarimetry
title Absolute optical chiral analysis using cavity-enhanced polarimetry
title_full Absolute optical chiral analysis using cavity-enhanced polarimetry
title_fullStr Absolute optical chiral analysis using cavity-enhanced polarimetry
title_full_unstemmed Absolute optical chiral analysis using cavity-enhanced polarimetry
title_short Absolute optical chiral analysis using cavity-enhanced polarimetry
title_sort absolute optical chiral analysis using cavity-enhanced polarimetry
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166628/
https://www.ncbi.nlm.nih.gov/pubmed/35658039
http://dx.doi.org/10.1126/sciadv.abm3749
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