Role of p38 MAP kinase in cancer stem cells and metastasis

Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer ste...

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Autores principales: Kudaravalli, Sriya, den Hollander, Petra, Mani, Sendurai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166676/
https://www.ncbi.nlm.nih.gov/pubmed/35501462
http://dx.doi.org/10.1038/s41388-022-02329-3
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author Kudaravalli, Sriya
den Hollander, Petra
Mani, Sendurai A.
author_facet Kudaravalli, Sriya
den Hollander, Petra
Mani, Sendurai A.
author_sort Kudaravalli, Sriya
collection PubMed
description Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer stem cells (CSCs) underlie treatment resistance and metastasis. p38 mitogen-activated protein kinase (p38 MAPK) is downstream of several CSC-specific signaling pathways, and it plays an important role in CSC development and maintenance and contributes to metastasis and chemoresistance. Therefore, the development of therapeutic approaches targeting p38 can sensitize tumors to chemotherapy and prevent metastatic progression.
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spelling pubmed-91666762022-06-05 Role of p38 MAP kinase in cancer stem cells and metastasis Kudaravalli, Sriya den Hollander, Petra Mani, Sendurai A. Oncogene Review Article Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer stem cells (CSCs) underlie treatment resistance and metastasis. p38 mitogen-activated protein kinase (p38 MAPK) is downstream of several CSC-specific signaling pathways, and it plays an important role in CSC development and maintenance and contributes to metastasis and chemoresistance. Therefore, the development of therapeutic approaches targeting p38 can sensitize tumors to chemotherapy and prevent metastatic progression. Nature Publishing Group UK 2022-04-30 2022 /pmc/articles/PMC9166676/ /pubmed/35501462 http://dx.doi.org/10.1038/s41388-022-02329-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kudaravalli, Sriya
den Hollander, Petra
Mani, Sendurai A.
Role of p38 MAP kinase in cancer stem cells and metastasis
title Role of p38 MAP kinase in cancer stem cells and metastasis
title_full Role of p38 MAP kinase in cancer stem cells and metastasis
title_fullStr Role of p38 MAP kinase in cancer stem cells and metastasis
title_full_unstemmed Role of p38 MAP kinase in cancer stem cells and metastasis
title_short Role of p38 MAP kinase in cancer stem cells and metastasis
title_sort role of p38 map kinase in cancer stem cells and metastasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166676/
https://www.ncbi.nlm.nih.gov/pubmed/35501462
http://dx.doi.org/10.1038/s41388-022-02329-3
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