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Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles
This paper studies the effectiveness of the integration of microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods, in order to find out the influences of these combinational methods in tumor necrosis. Hepatocellular carcinoma is a kind of liver cancer th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166745/ https://www.ncbi.nlm.nih.gov/pubmed/35665760 http://dx.doi.org/10.1038/s41598-022-13420-w |
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author | Kabiri, Saeedeh Rezaei, Fatemeh |
author_facet | Kabiri, Saeedeh Rezaei, Fatemeh |
author_sort | Kabiri, Saeedeh |
collection | PubMed |
description | This paper studies the effectiveness of the integration of microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods, in order to find out the influences of these combinational methods in tumor necrosis. Hepatocellular carcinoma is a kind of liver cancer that usually has a complicated structure, including both of superficial and deep sections. In current research, in deep regions of cancerous tissue, microwave antenna is utilized and in superficial regions, laser beams are irradiated. A Pulsed laser with heating time of 50 s and cooling time of 20 s is utilized for hyperthermia treatment. It should be mentioned that gold nanorods are injected into the tumorous region to enhance the treatment process and reduce the patient’s exposure time. Simulation results showed that at the first step, without any injection of gold nanoparticles, 0.17% of the tumor’s volume encountered necrosis, while at the next stage, after injection of gold nanorods, the necrosis rate increased to 35%, which demonstrates the efficiency of gold nanorods injection on the tumor treatments. Furthermore, the combinational applying of both microwave antenna and laser illumination can eradiate the tumor tissue completely. |
format | Online Article Text |
id | pubmed-9166745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91667452022-06-05 Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles Kabiri, Saeedeh Rezaei, Fatemeh Sci Rep Article This paper studies the effectiveness of the integration of microwave field irradiation and laser emission in liver cancer therapy with the aid of gold nanorods, in order to find out the influences of these combinational methods in tumor necrosis. Hepatocellular carcinoma is a kind of liver cancer that usually has a complicated structure, including both of superficial and deep sections. In current research, in deep regions of cancerous tissue, microwave antenna is utilized and in superficial regions, laser beams are irradiated. A Pulsed laser with heating time of 50 s and cooling time of 20 s is utilized for hyperthermia treatment. It should be mentioned that gold nanorods are injected into the tumorous region to enhance the treatment process and reduce the patient’s exposure time. Simulation results showed that at the first step, without any injection of gold nanoparticles, 0.17% of the tumor’s volume encountered necrosis, while at the next stage, after injection of gold nanorods, the necrosis rate increased to 35%, which demonstrates the efficiency of gold nanorods injection on the tumor treatments. Furthermore, the combinational applying of both microwave antenna and laser illumination can eradiate the tumor tissue completely. Nature Publishing Group UK 2022-06-03 /pmc/articles/PMC9166745/ /pubmed/35665760 http://dx.doi.org/10.1038/s41598-022-13420-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kabiri, Saeedeh Rezaei, Fatemeh Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title | Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title_full | Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title_fullStr | Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title_full_unstemmed | Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title_short | Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
title_sort | liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166745/ https://www.ncbi.nlm.nih.gov/pubmed/35665760 http://dx.doi.org/10.1038/s41598-022-13420-w |
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