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Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats
This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension. 2K-1C rats were treated with nobiletin (15 or 30 mg/kg/day) or losartan (10 mg/kg/day) for 4 weeks (n = 8/group). Nobiletin (30 mg/kg) reduced...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166784/ https://www.ncbi.nlm.nih.gov/pubmed/35662276 http://dx.doi.org/10.1038/s41598-022-13513-6 |
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author | Iampanichakul, Metee Poasakate, Anuson Potue, Prapassorn Rattanakanokchai, Siwayu Maneesai, Putcharawipa Prachaney, Parichat Settheetham-Ishida, Wannapa Pakdeechote, Poungrat |
author_facet | Iampanichakul, Metee Poasakate, Anuson Potue, Prapassorn Rattanakanokchai, Siwayu Maneesai, Putcharawipa Prachaney, Parichat Settheetham-Ishida, Wannapa Pakdeechote, Poungrat |
author_sort | Iampanichakul, Metee |
collection | PubMed |
description | This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension. 2K-1C rats were treated with nobiletin (15 or 30 mg/kg/day) or losartan (10 mg/kg/day) for 4 weeks (n = 8/group). Nobiletin (30 mg/kg) reduced high levels of blood pressure and circulating angiotensin II and angiotensin-converting enzyme activity in 2K-1C rats. Left ventricular (LV) dysfunction and remodelling in 2K-1C rats were alleviated in the nobiletin-treated group (P < 0.05). Nobiletin reduced the upregulation of Ang II type I receptor (AT(1)R)/JAK (Janus kinase)/STAT (signal transducer and activator of transcription) protein expression in cardiac tissue of 2K-1C rats (P < 0.05). The reduction in kidney function, and accumulation of renal fibrosis in 2K-1C rats were alleviated by nobiletin (P < 0.05). Overexpression of AT(1)R and NADPH oxidase 4 (Nox4) protein in nonclipped kidney tissue was suppressed in the nobiletin-treated group (P < 0.05). The elevations in oxidative stress parameters and the reductions in antioxidant enzymes were attenuated in 2K-1C rats treated with nobiletin (P < 0.05). In summary, nobiletin had renin-angiotensin system inhibitory and antioxidant effects and attenuated LV dysfunction and remodelling via restoration of the AT(1)R/JAK/STAT pathway. Nobiletin also resolved renal damage that was related to modulation of the AT(1)R/Nox4 cascade in 2K-1C hypertension. |
format | Online Article Text |
id | pubmed-9166784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91667842022-06-05 Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats Iampanichakul, Metee Poasakate, Anuson Potue, Prapassorn Rattanakanokchai, Siwayu Maneesai, Putcharawipa Prachaney, Parichat Settheetham-Ishida, Wannapa Pakdeechote, Poungrat Sci Rep Article This study investigated the effects of nobiletin on cardiorenal changes and the underlying mechanisms involved in two-kidney, one-clip (2K-1C) hypertension. 2K-1C rats were treated with nobiletin (15 or 30 mg/kg/day) or losartan (10 mg/kg/day) for 4 weeks (n = 8/group). Nobiletin (30 mg/kg) reduced high levels of blood pressure and circulating angiotensin II and angiotensin-converting enzyme activity in 2K-1C rats. Left ventricular (LV) dysfunction and remodelling in 2K-1C rats were alleviated in the nobiletin-treated group (P < 0.05). Nobiletin reduced the upregulation of Ang II type I receptor (AT(1)R)/JAK (Janus kinase)/STAT (signal transducer and activator of transcription) protein expression in cardiac tissue of 2K-1C rats (P < 0.05). The reduction in kidney function, and accumulation of renal fibrosis in 2K-1C rats were alleviated by nobiletin (P < 0.05). Overexpression of AT(1)R and NADPH oxidase 4 (Nox4) protein in nonclipped kidney tissue was suppressed in the nobiletin-treated group (P < 0.05). The elevations in oxidative stress parameters and the reductions in antioxidant enzymes were attenuated in 2K-1C rats treated with nobiletin (P < 0.05). In summary, nobiletin had renin-angiotensin system inhibitory and antioxidant effects and attenuated LV dysfunction and remodelling via restoration of the AT(1)R/JAK/STAT pathway. Nobiletin also resolved renal damage that was related to modulation of the AT(1)R/Nox4 cascade in 2K-1C hypertension. Nature Publishing Group UK 2022-06-03 /pmc/articles/PMC9166784/ /pubmed/35662276 http://dx.doi.org/10.1038/s41598-022-13513-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Iampanichakul, Metee Poasakate, Anuson Potue, Prapassorn Rattanakanokchai, Siwayu Maneesai, Putcharawipa Prachaney, Parichat Settheetham-Ishida, Wannapa Pakdeechote, Poungrat Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title | Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title_full | Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title_fullStr | Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title_full_unstemmed | Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title_short | Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats |
title_sort | nobiletin resolves left ventricular and renal changes in 2k-1c hypertensive rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166784/ https://www.ncbi.nlm.nih.gov/pubmed/35662276 http://dx.doi.org/10.1038/s41598-022-13513-6 |
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