An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance

Loss-of-function variants in the BRCA1 and BRCA2 susceptibility genes predispose carriers to breast and/or ovarian cancer. The use of germline testing panels containing these genes has grown dramatically, but the interpretation of the results has been complicated by the identification of many sequen...

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Detalles Bibliográficos
Autores principales: Iversen, Edwin S., Lipton, Gary, Hart, Steven N., Lee, Kun Y., Hu, Chunling, Polley, Eric C., Pesaran, Tina, Yussuf, Amal, LaDuca, Holly, Chao, Elizabeth, Karam, Rachid, Goldgar, David E., Couch, Fergus J., Monteiro, Alvaro N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166814/
https://www.ncbi.nlm.nih.gov/pubmed/35665744
http://dx.doi.org/10.1038/s41525-022-00302-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166814/
https://www.ncbi.nlm.nih.gov/pubmed/35665744
http://dx.doi.org/10.1038/s41525-022-00302-3

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