Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept t...

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Detalles Bibliográficos
Autores principales: Rath, Matthias, Schwefel, Konrad, Malinverno, Matteo, Skowronek, Dariush, Leopoldi, Alexandra, Pilz, Robin A., Biedenweg, Doreen, Bekeschus, Sander, Penninger, Josef M., Dejana, Elisabetta, Felbor, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166869/
https://www.ncbi.nlm.nih.gov/pubmed/35661927
http://dx.doi.org/10.1007/s00018-022-04355-6

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