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Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model

BACKGROUND: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet-induced NASH in the murine model by modulating NLRP3...

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Detalles Bibliográficos
Autores principales:	Saha, Moumita, Manna, Krishnendu, Das Saha, Krishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166960/ https://www.ncbi.nlm.nih.gov/pubmed/35668917 http://dx.doi.org/10.2147/JIR.S343236

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