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EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture

BACKGROUND: In previous studies, electroacupuncture (EA) with 2/15 Hz has been shown to enhance the sedative effects in general anesthesia patients. Central lateral thalamic stimulation of 50 Hz showed an arousal effect in macaques. Therefore, it is worth studying the sedative effect of EA at periph...

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Autores principales: Zhu, Shu-ying, Ma, Jin, Wang, Ze-ru, Chai, Qing, Yan, Liang-chun, Song, Jun, Shu, Jin-jun, Wang, Huai-ming, Chen, Yi-ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167085/
https://www.ncbi.nlm.nih.gov/pubmed/35668776
http://dx.doi.org/10.1155/2022/2440609
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author Zhu, Shu-ying
Ma, Jin
Wang, Ze-ru
Chai, Qing
Yan, Liang-chun
Song, Jun
Shu, Jin-jun
Wang, Huai-ming
Chen, Yi-ding
author_facet Zhu, Shu-ying
Ma, Jin
Wang, Ze-ru
Chai, Qing
Yan, Liang-chun
Song, Jun
Shu, Jin-jun
Wang, Huai-ming
Chen, Yi-ding
author_sort Zhu, Shu-ying
collection PubMed
description BACKGROUND: In previous studies, electroacupuncture (EA) with 2/15 Hz has been shown to enhance the sedative effects in general anesthesia patients. Central lateral thalamic stimulation of 50 Hz showed an arousal effect in macaques. Therefore, it is worth studying the sedative effect of EA at peripheral acupoints with different frequencies, especially the frequency of around 50 Hz. METHODS: Rats were anesthetized under the constant infusion of propofol and EA at Zusanli (ST36) and Neiguan (PC6) locations. Electroencephalography (EEG) and heart rate were continuously recorded before and after the intervention by EA in the C group (control), LEA group (low-frequency group, 2/15 Hz diffuse/dense wave EA stimulation), and HEA group (high-frequency group, 50 Hz stimulation). RESULTS: In the LEA group, a significant increase in the power of the delta component with a decrease in the alpha component (p < 0.05) was observed after EA stimulation. In the HEA group, significant increases in the powers of alpha and beta components of EEG (p < 0.05) and a decrease in the delta component of EEG were observed (p < 0.05). The phenomenon is also shown in full-frequency waves. In addition, a significant decrease in the low-frequency/high-frequency ratio parameter was observed in the LEA group. CONCLUSIONS: EA at bilateral ST36 and PC6 can enhance the sedative effects of propofol anesthesia in low-frequency stimulation but lighten the sedative effects in high-frequency (50 Hz) stimulation. The sympathetic-vagal balance was affected due to low-frequency EA.
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spelling pubmed-91670852022-06-05 EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture Zhu, Shu-ying Ma, Jin Wang, Ze-ru Chai, Qing Yan, Liang-chun Song, Jun Shu, Jin-jun Wang, Huai-ming Chen, Yi-ding Evid Based Complement Alternat Med Research Article BACKGROUND: In previous studies, electroacupuncture (EA) with 2/15 Hz has been shown to enhance the sedative effects in general anesthesia patients. Central lateral thalamic stimulation of 50 Hz showed an arousal effect in macaques. Therefore, it is worth studying the sedative effect of EA at peripheral acupoints with different frequencies, especially the frequency of around 50 Hz. METHODS: Rats were anesthetized under the constant infusion of propofol and EA at Zusanli (ST36) and Neiguan (PC6) locations. Electroencephalography (EEG) and heart rate were continuously recorded before and after the intervention by EA in the C group (control), LEA group (low-frequency group, 2/15 Hz diffuse/dense wave EA stimulation), and HEA group (high-frequency group, 50 Hz stimulation). RESULTS: In the LEA group, a significant increase in the power of the delta component with a decrease in the alpha component (p < 0.05) was observed after EA stimulation. In the HEA group, significant increases in the powers of alpha and beta components of EEG (p < 0.05) and a decrease in the delta component of EEG were observed (p < 0.05). The phenomenon is also shown in full-frequency waves. In addition, a significant decrease in the low-frequency/high-frequency ratio parameter was observed in the LEA group. CONCLUSIONS: EA at bilateral ST36 and PC6 can enhance the sedative effects of propofol anesthesia in low-frequency stimulation but lighten the sedative effects in high-frequency (50 Hz) stimulation. The sympathetic-vagal balance was affected due to low-frequency EA. Hindawi 2022-05-27 /pmc/articles/PMC9167085/ /pubmed/35668776 http://dx.doi.org/10.1155/2022/2440609 Text en Copyright © 2022 Shu-ying Zhu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Shu-ying
Ma, Jin
Wang, Ze-ru
Chai, Qing
Yan, Liang-chun
Song, Jun
Shu, Jin-jun
Wang, Huai-ming
Chen, Yi-ding
EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title_full EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title_fullStr EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title_full_unstemmed EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title_short EEG and ECG Power Spectrum Analysis of Sedative Effects on Propofol-Anesthetized Rats with Electroacupuncture
title_sort eeg and ecg power spectrum analysis of sedative effects on propofol-anesthetized rats with electroacupuncture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167085/
https://www.ncbi.nlm.nih.gov/pubmed/35668776
http://dx.doi.org/10.1155/2022/2440609
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