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Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19

In this study, an autonomous type deterministic nonlinear mathematical model that explains the transmission dynamics of COVID-19 is proposed and analyzed by considering awareness campaign between humans and infectives of COVID-19 asymptomatic human immigrants. Unlike some of other previous model stu...

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Autores principales: Anteneh, Alemzewde Ayalew, Bazezew, Yezbalem Molla, Palanisamy, Shanmugasundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167104/
https://www.ncbi.nlm.nih.gov/pubmed/35669719
http://dx.doi.org/10.1155/2022/6260262
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author Anteneh, Alemzewde Ayalew
Bazezew, Yezbalem Molla
Palanisamy, Shanmugasundaram
author_facet Anteneh, Alemzewde Ayalew
Bazezew, Yezbalem Molla
Palanisamy, Shanmugasundaram
author_sort Anteneh, Alemzewde Ayalew
collection PubMed
description In this study, an autonomous type deterministic nonlinear mathematical model that explains the transmission dynamics of COVID-19 is proposed and analyzed by considering awareness campaign between humans and infectives of COVID-19 asymptomatic human immigrants. Unlike some of other previous model studies about this disease, we have taken into account the impact of awareness c between humans and infectives of COVID-19 asymptomatic human immigrants on COVID-19 transmission. The existence and uniqueness of model solutions are proved using the fundamental existence and uniqueness theorem. We also showed positivity and the invariant region of the model system with initial conditions in a certain meaningful set. The model exhibits two equilibria: disease (COVID-19) free and COVID-19 persistent equilibrium points and also the basic reproduction number, R(0) which is derived via the help of next generation approach. Our analytical analysis showed that disease-free equilibrium point is obtained only in the absence of asymptomatic COVID-19 human immigrants and disease (COVID-19) in the population. Moreover, local stability of disease-free equilibrium point is verified via the help of Jacobian and Hurwitz criteria, and the global stability is verified using Castillo-Chavez and Song approach. The disease-free equilibrium point is both locally and globally asymptotically stable whenever R(0) < 1, so that disease dies out in the population. If  R(0) > 1, then disease-free equilibrium point is unstable while the endemic equilibrium point exists and stable, which implies the disease persist and reinvasion will occur within a population. Furthermore, sensitivity analysis of the basic reproduction number, R(0) with respect to model parameters, is computed to identify the most influential parameters in transmission as well as in the control of COVID-19. Finally, some numerical simulations are illustrated to verify the theoretical results of the model.
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spelling pubmed-91671042022-06-05 Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19 Anteneh, Alemzewde Ayalew Bazezew, Yezbalem Molla Palanisamy, Shanmugasundaram Biomed Res Int Research Article In this study, an autonomous type deterministic nonlinear mathematical model that explains the transmission dynamics of COVID-19 is proposed and analyzed by considering awareness campaign between humans and infectives of COVID-19 asymptomatic human immigrants. Unlike some of other previous model studies about this disease, we have taken into account the impact of awareness c between humans and infectives of COVID-19 asymptomatic human immigrants on COVID-19 transmission. The existence and uniqueness of model solutions are proved using the fundamental existence and uniqueness theorem. We also showed positivity and the invariant region of the model system with initial conditions in a certain meaningful set. The model exhibits two equilibria: disease (COVID-19) free and COVID-19 persistent equilibrium points and also the basic reproduction number, R(0) which is derived via the help of next generation approach. Our analytical analysis showed that disease-free equilibrium point is obtained only in the absence of asymptomatic COVID-19 human immigrants and disease (COVID-19) in the population. Moreover, local stability of disease-free equilibrium point is verified via the help of Jacobian and Hurwitz criteria, and the global stability is verified using Castillo-Chavez and Song approach. The disease-free equilibrium point is both locally and globally asymptotically stable whenever R(0) < 1, so that disease dies out in the population. If  R(0) > 1, then disease-free equilibrium point is unstable while the endemic equilibrium point exists and stable, which implies the disease persist and reinvasion will occur within a population. Furthermore, sensitivity analysis of the basic reproduction number, R(0) with respect to model parameters, is computed to identify the most influential parameters in transmission as well as in the control of COVID-19. Finally, some numerical simulations are illustrated to verify the theoretical results of the model. Hindawi 2022-05-28 /pmc/articles/PMC9167104/ /pubmed/35669719 http://dx.doi.org/10.1155/2022/6260262 Text en Copyright © 2022 Alemzewde Ayalew Anteneh et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anteneh, Alemzewde Ayalew
Bazezew, Yezbalem Molla
Palanisamy, Shanmugasundaram
Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title_full Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title_fullStr Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title_full_unstemmed Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title_short Mathematical Model and Analysis on the Impact of Awareness Campaign and Asymptomatic Human Immigrants in the Transmission of COVID-19
title_sort mathematical model and analysis on the impact of awareness campaign and asymptomatic human immigrants in the transmission of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167104/
https://www.ncbi.nlm.nih.gov/pubmed/35669719
http://dx.doi.org/10.1155/2022/6260262
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