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The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead...

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Autores principales: Rogulska, Karolina, Wojciechowska-Koszko, Iwona, Dołęgowska, Barbara, Kwiatkowska, Ewa, Roszkowska, Paulina, Kapczuk, Patrycja, Kosik-Bogacka, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167141/
https://www.ncbi.nlm.nih.gov/pubmed/35669103
http://dx.doi.org/10.1155/2022/6572338
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author Rogulska, Karolina
Wojciechowska-Koszko, Iwona
Dołęgowska, Barbara
Kwiatkowska, Ewa
Roszkowska, Paulina
Kapczuk, Patrycja
Kosik-Bogacka, Danuta
author_facet Rogulska, Karolina
Wojciechowska-Koszko, Iwona
Dołęgowska, Barbara
Kwiatkowska, Ewa
Roszkowska, Paulina
Kapczuk, Patrycja
Kosik-Bogacka, Danuta
author_sort Rogulska, Karolina
collection PubMed
description Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead to the rejection of the transplanted organ. The gold standard for evaluating rejection of the transplanted kidney by the recipient's organism is a biopsy of this organ. However, due to the high invasiveness of this procedure, alternative diagnostic methods are being sought. Therefore, the biomarkers may play an essential predictive role in transplant rejection. A review of the most promising biomarkers for early diagnosis and prognosis prediction of allogenic kidney transplant rejection summarizes novel data on neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), C-X-C motif chemokine 10 (CXCL-10), cystatin C (CysC), osteopontin (OPN), and clusterin (CLU) and analyses the dynamics of changes of the biomarkers mentioned above in kidney diseases and the mechanism of rejection of the transplanted kidney.
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spelling pubmed-91671412022-06-05 The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection Rogulska, Karolina Wojciechowska-Koszko, Iwona Dołęgowska, Barbara Kwiatkowska, Ewa Roszkowska, Paulina Kapczuk, Patrycja Kosik-Bogacka, Danuta J Immunol Res Review Article Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead to the rejection of the transplanted organ. The gold standard for evaluating rejection of the transplanted kidney by the recipient's organism is a biopsy of this organ. However, due to the high invasiveness of this procedure, alternative diagnostic methods are being sought. Therefore, the biomarkers may play an essential predictive role in transplant rejection. A review of the most promising biomarkers for early diagnosis and prognosis prediction of allogenic kidney transplant rejection summarizes novel data on neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), C-X-C motif chemokine 10 (CXCL-10), cystatin C (CysC), osteopontin (OPN), and clusterin (CLU) and analyses the dynamics of changes of the biomarkers mentioned above in kidney diseases and the mechanism of rejection of the transplanted kidney. Hindawi 2022-05-28 /pmc/articles/PMC9167141/ /pubmed/35669103 http://dx.doi.org/10.1155/2022/6572338 Text en Copyright © 2022 Karolina Rogulska et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rogulska, Karolina
Wojciechowska-Koszko, Iwona
Dołęgowska, Barbara
Kwiatkowska, Ewa
Roszkowska, Paulina
Kapczuk, Patrycja
Kosik-Bogacka, Danuta
The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title_full The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title_fullStr The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title_full_unstemmed The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title_short The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection
title_sort most promising biomarkers of allogeneic kidney transplant rejection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167141/
https://www.ncbi.nlm.nih.gov/pubmed/35669103
http://dx.doi.org/10.1155/2022/6572338
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