Detection of impurities in dietary supplements containing l-tryptophan

Impurities in nine dietary supplements containing l-tryptophan were evaluated using an HPLC methodology. In five tested products, the total impurities were higher than the thresholds described in the Food Chemical Codex or implemented in the EU for pharmaceutical grade l-tryptophan. In addition, liq...

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Autores principales: Karakawa, Sachise, Nakayama, Akira, Ohtsuka, Naoto, Sato, Katsuma, Smriga, Miro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167196/
https://www.ncbi.nlm.nih.gov/pubmed/35043227
http://dx.doi.org/10.1007/s00726-022-03125-9
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author Karakawa, Sachise
Nakayama, Akira
Ohtsuka, Naoto
Sato, Katsuma
Smriga, Miro
author_facet Karakawa, Sachise
Nakayama, Akira
Ohtsuka, Naoto
Sato, Katsuma
Smriga, Miro
author_sort Karakawa, Sachise
collection PubMed
description Impurities in nine dietary supplements containing l-tryptophan were evaluated using an HPLC methodology. In five tested products, the total impurities were higher than the thresholds described in the Food Chemical Codex or implemented in the EU for pharmaceutical grade l-tryptophan. In addition, liquid chromatography–mass spectrometry was used to specifically test for the presence of 1,1′-ethylidenebis-l-tryptophan (EBT). None of the tested products contained detectable amounts of EBT. High amounts of unidentified impurities in some dietary supplements point to potential health risks.
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spelling pubmed-91671962022-06-06 Detection of impurities in dietary supplements containing l-tryptophan Karakawa, Sachise Nakayama, Akira Ohtsuka, Naoto Sato, Katsuma Smriga, Miro Amino Acids Short Communication Impurities in nine dietary supplements containing l-tryptophan were evaluated using an HPLC methodology. In five tested products, the total impurities were higher than the thresholds described in the Food Chemical Codex or implemented in the EU for pharmaceutical grade l-tryptophan. In addition, liquid chromatography–mass spectrometry was used to specifically test for the presence of 1,1′-ethylidenebis-l-tryptophan (EBT). None of the tested products contained detectable amounts of EBT. High amounts of unidentified impurities in some dietary supplements point to potential health risks. Springer Vienna 2022-01-18 2022 /pmc/articles/PMC9167196/ /pubmed/35043227 http://dx.doi.org/10.1007/s00726-022-03125-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Karakawa, Sachise
Nakayama, Akira
Ohtsuka, Naoto
Sato, Katsuma
Smriga, Miro
Detection of impurities in dietary supplements containing l-tryptophan
title Detection of impurities in dietary supplements containing l-tryptophan
title_full Detection of impurities in dietary supplements containing l-tryptophan
title_fullStr Detection of impurities in dietary supplements containing l-tryptophan
title_full_unstemmed Detection of impurities in dietary supplements containing l-tryptophan
title_short Detection of impurities in dietary supplements containing l-tryptophan
title_sort detection of impurities in dietary supplements containing l-tryptophan
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167196/
https://www.ncbi.nlm.nih.gov/pubmed/35043227
http://dx.doi.org/10.1007/s00726-022-03125-9
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