OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy

OPTN is an autophagy receptor involved in autophagic degradation. Here we studied the role of OPTN in attenuating the neurotoxicity induced by mutated Tau protein. We constructed recombinant adeno-associated viruses with OPTN and Tau-P301L genes, respectively. Through virus coinfection on neuronal c...

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Detalles Bibliográficos
Autores principales: Xu, Yin, Liu, Yun, Chen, Xi, Xu, Qia, Liu, Liwei, Liu, Hui, Guo, Ruowen, Qin, Yide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167278/
https://www.ncbi.nlm.nih.gov/pubmed/35662233
http://dx.doi.org/10.1038/s41398-022-02004-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167278/
https://www.ncbi.nlm.nih.gov/pubmed/35662233
http://dx.doi.org/10.1038/s41398-022-02004-x

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