The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy

Transient receptor potential melastatin 8 (TRPM8) functions as a Ca(2+)-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying mechanisms are unclear. Here, we found that lymph...

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Detalles Bibliográficos
Autores principales: Huang, Yuan, Li, Shi, Liu, Qinfeng, Wang, Zhijie, Li, Shunyao, Liu, Lei, Zhao, Weiwei, Wang, Kai, Zhang, Rui, Wang, Longfei, Wang, Ming, William Ali, Declan, Michalak, Marek, Chen, Xing-Zhen, Zhou, Cefan, Tang, Jingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167300/
https://www.ncbi.nlm.nih.gov/pubmed/35665750
http://dx.doi.org/10.1038/s41419-022-04977-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167300/
https://www.ncbi.nlm.nih.gov/pubmed/35665750
http://dx.doi.org/10.1038/s41419-022-04977-5

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