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Evaluation of the Pharmacokinetics and Safety of AMG 986 Tablet and Capsule Formulations in Healthy Adult Subjects: A Phase I, Open-Label, Randomized Study

BACKGROUND AND OBJECTIVE: AMG 986 is a first-in-class, novel apelin receptor small molecule agonist initially developed for the treatment of heart failure. The current phase I study was conducted to evaluate the pharmacokinetics and safety of a single-dose 200-mg capsule formulation of AMG 986 relat...

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Detalles Bibliográficos
Autores principales:	Trivedi, Ashit, Kiang, Y.-H., Saw, Robert E., Cheng, Guilong Charles, Mather, Omar, Vega, Silvia, Hellawell, Jennifer, Lee, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167409/ https://www.ncbi.nlm.nih.gov/pubmed/35412220 http://dx.doi.org/10.1007/s40268-022-00388-1

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