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Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats

The type of diet is very important for the maintenance of health and nutrition. How the sole source of carbohydrates from rice- or flour-based diet affect blood sugar has not been elucidated for a long time. In order to explore the effects of these diets, sixty SD rats were randomly divided into thr...

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Autores principales: Wang, Siyu, Wang, Wenjun, Mao, Hongmei, Zhu, Mingyu, Xu, Zihan, Wang, Jun, Zhang, Xuesong, Li, Baolong, Xiang, Xuesong, Wang, Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167423/
https://www.ncbi.nlm.nih.gov/pubmed/35673359
http://dx.doi.org/10.3389/fnut.2022.887757
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author Wang, Siyu
Wang, Wenjun
Mao, Hongmei
Zhu, Mingyu
Xu, Zihan
Wang, Jun
Zhang, Xuesong
Li, Baolong
Xiang, Xuesong
Wang, Zhu
author_facet Wang, Siyu
Wang, Wenjun
Mao, Hongmei
Zhu, Mingyu
Xu, Zihan
Wang, Jun
Zhang, Xuesong
Li, Baolong
Xiang, Xuesong
Wang, Zhu
author_sort Wang, Siyu
collection PubMed
description The type of diet is very important for the maintenance of health and nutrition. How the sole source of carbohydrates from rice- or flour-based diet affect blood sugar has not been elucidated for a long time. In order to explore the effects of these diets, sixty SD rats were randomly divided into three groups: control group (C group, AIN-93, standard diet), rice diet group (R group), and flour diet group (F group). All the rats were fed for 7 weeks in total by the assigned diets for 4 weeks (stage 1, S1) and all by the AIN-93 diet for 3 weeks (stage 2, S2). The body weights of all the rats were monitored and serum samples were taken for testing blood glucose, biochemical indicators and untargeted lipidome. It was found that both rice and flour-based diets caused weight gain, but the flour diet had a significant increase in blood sugar and low-density lipoprotein (LDL), while a significant decrease in albumin (ALB) and triglycerides (TG). Twenty-three and 148 lipids were changed by lipidomics in the rice diet group and flour diet group, respectively, and two lipids showed the same changes in the two groups, all belonging to TGs, namely TG (16:0/16:0/16:1) and TG (16:0/16:1/18:2), which showed that a single diet source had a significant effect on the health of rats. Fortunately, we can recover this effect through the subsequent standard diet, allowing the rats to return to normal blood sugar, weight and biochemical indicators. A model can predict the diet types through the logistic regression method. Finally, we proposed that a single diet increased blood sugar and weight through a decrease in TGs, and blood sugar and weight returned to normal after a standard diet. Taken together, the short-term negative effects caused by a single diet can be recovered by a standard diet and further proves the importance of diet types.
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spelling pubmed-91674232022-06-06 Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats Wang, Siyu Wang, Wenjun Mao, Hongmei Zhu, Mingyu Xu, Zihan Wang, Jun Zhang, Xuesong Li, Baolong Xiang, Xuesong Wang, Zhu Front Nutr Nutrition The type of diet is very important for the maintenance of health and nutrition. How the sole source of carbohydrates from rice- or flour-based diet affect blood sugar has not been elucidated for a long time. In order to explore the effects of these diets, sixty SD rats were randomly divided into three groups: control group (C group, AIN-93, standard diet), rice diet group (R group), and flour diet group (F group). All the rats were fed for 7 weeks in total by the assigned diets for 4 weeks (stage 1, S1) and all by the AIN-93 diet for 3 weeks (stage 2, S2). The body weights of all the rats were monitored and serum samples were taken for testing blood glucose, biochemical indicators and untargeted lipidome. It was found that both rice and flour-based diets caused weight gain, but the flour diet had a significant increase in blood sugar and low-density lipoprotein (LDL), while a significant decrease in albumin (ALB) and triglycerides (TG). Twenty-three and 148 lipids were changed by lipidomics in the rice diet group and flour diet group, respectively, and two lipids showed the same changes in the two groups, all belonging to TGs, namely TG (16:0/16:0/16:1) and TG (16:0/16:1/18:2), which showed that a single diet source had a significant effect on the health of rats. Fortunately, we can recover this effect through the subsequent standard diet, allowing the rats to return to normal blood sugar, weight and biochemical indicators. A model can predict the diet types through the logistic regression method. Finally, we proposed that a single diet increased blood sugar and weight through a decrease in TGs, and blood sugar and weight returned to normal after a standard diet. Taken together, the short-term negative effects caused by a single diet can be recovered by a standard diet and further proves the importance of diet types. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9167423/ /pubmed/35673359 http://dx.doi.org/10.3389/fnut.2022.887757 Text en Copyright © 2022 Wang, Wang, Mao, Zhu, Xu, Wang, Zhang, Li, Xiang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Wang, Siyu
Wang, Wenjun
Mao, Hongmei
Zhu, Mingyu
Xu, Zihan
Wang, Jun
Zhang, Xuesong
Li, Baolong
Xiang, Xuesong
Wang, Zhu
Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title_full Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title_fullStr Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title_full_unstemmed Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title_short Lipidomics Reveals That Rice or Flour as a Single Source of Carbohydrates Cause Adverse Health Effects in Rats
title_sort lipidomics reveals that rice or flour as a single source of carbohydrates cause adverse health effects in rats
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167423/
https://www.ncbi.nlm.nih.gov/pubmed/35673359
http://dx.doi.org/10.3389/fnut.2022.887757
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