Synthetic condensate size correlates with yeast replicative cell age

Yeast divides asymmetrically, with an aging mother cell and a ‘rejuvenated’ daughter cell, and serves as a model organism for studying aging. At the same time, determining the age of yeast cells is technically challenging, requiring complex experimental setups or genetic strategies. We developed a s...

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Detalles Bibliográficos
Autores principales: Heidenreich, Meta, Georgeson, Joseph M, Nadav, Yotam, Levy, Emmanuel D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167435/
https://www.ncbi.nlm.nih.gov/pubmed/35673323
http://dx.doi.org/10.17912/micropub.biology.000582
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author Heidenreich, Meta
Georgeson, Joseph M
Nadav, Yotam
Levy, Emmanuel D
author_facet Heidenreich, Meta
Georgeson, Joseph M
Nadav, Yotam
Levy, Emmanuel D
author_sort Heidenreich, Meta
collection PubMed
description Yeast divides asymmetrically, with an aging mother cell and a ‘rejuvenated’ daughter cell, and serves as a model organism for studying aging. At the same time, determining the age of yeast cells is technically challenging, requiring complex experimental setups or genetic strategies. We developed a synthetic system composed of two interacting oligomers, which forms condensates in living yeast cells. Here, we report that these synthetic condensates' size correlates with yeast replicative age, making these condensates age reporters for this model organism.
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spelling pubmed-91674352022-06-06 Synthetic condensate size correlates with yeast replicative cell age Heidenreich, Meta Georgeson, Joseph M Nadav, Yotam Levy, Emmanuel D MicroPubl Biol New Finding Yeast divides asymmetrically, with an aging mother cell and a ‘rejuvenated’ daughter cell, and serves as a model organism for studying aging. At the same time, determining the age of yeast cells is technically challenging, requiring complex experimental setups or genetic strategies. We developed a synthetic system composed of two interacting oligomers, which forms condensates in living yeast cells. Here, we report that these synthetic condensates' size correlates with yeast replicative age, making these condensates age reporters for this model organism. Caltech Library 2022-06-03 /pmc/articles/PMC9167435/ /pubmed/35673323 http://dx.doi.org/10.17912/micropub.biology.000582 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Heidenreich, Meta
Georgeson, Joseph M
Nadav, Yotam
Levy, Emmanuel D
Synthetic condensate size correlates with yeast replicative cell age
title Synthetic condensate size correlates with yeast replicative cell age
title_full Synthetic condensate size correlates with yeast replicative cell age
title_fullStr Synthetic condensate size correlates with yeast replicative cell age
title_full_unstemmed Synthetic condensate size correlates with yeast replicative cell age
title_short Synthetic condensate size correlates with yeast replicative cell age
title_sort synthetic condensate size correlates with yeast replicative cell age
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167435/
https://www.ncbi.nlm.nih.gov/pubmed/35673323
http://dx.doi.org/10.17912/micropub.biology.000582
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AT nadavyotam syntheticcondensatesizecorrelateswithyeastreplicativecellage
AT levyemmanueld syntheticcondensatesizecorrelateswithyeastreplicativecellage

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