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MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Variou...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167543/ https://www.ncbi.nlm.nih.gov/pubmed/35659780 http://dx.doi.org/10.1186/s40364-022-00382-4 |
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author | Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam |
author_facet | Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam |
author_sort | Hamidi, Amir Abbas |
collection | PubMed |
description | Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients. |
format | Online Article Text |
id | pubmed-9167543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91675432022-06-06 MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam Biomark Res Review Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients. BioMed Central 2022-06-04 /pmc/articles/PMC9167543/ /pubmed/35659780 http://dx.doi.org/10.1186/s40364-022-00382-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title_full | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title_fullStr | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title_full_unstemmed | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title_short | MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer |
title_sort | micrornas as the critical regulators of cell migration and invasion in thyroid cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167543/ https://www.ncbi.nlm.nih.gov/pubmed/35659780 http://dx.doi.org/10.1186/s40364-022-00382-4 |
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