Cargando…

MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer

Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Variou...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamidi, Amir Abbas, Taghehchian, Negin, Basirat, Zahra, Zangouei, Amir Sadra, Moghbeli, Meysam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167543/
https://www.ncbi.nlm.nih.gov/pubmed/35659780
http://dx.doi.org/10.1186/s40364-022-00382-4
_version_ 1784720821553463296
author Hamidi, Amir Abbas
Taghehchian, Negin
Basirat, Zahra
Zangouei, Amir Sadra
Moghbeli, Meysam
author_facet Hamidi, Amir Abbas
Taghehchian, Negin
Basirat, Zahra
Zangouei, Amir Sadra
Moghbeli, Meysam
author_sort Hamidi, Amir Abbas
collection PubMed
description Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients.
format Online
Article
Text
id pubmed-9167543
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91675432022-06-06 MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer Hamidi, Amir Abbas Taghehchian, Negin Basirat, Zahra Zangouei, Amir Sadra Moghbeli, Meysam Biomark Res Review Thyroid cancer (TC) is one of the most frequent endocrine malignancies that is more common among females. Tumor recurrence is one of the most important clinical manifestations in differentiated TC which is associated with different factors including age, tumor size, and histological features. Various molecular processes such as genetic or epigenetic modifications and non-coding RNAs are also involved in TC progression and metastasis. The epithelial-to-mesenchymal transition (EMT) is an important biological process during tumor invasion and migration that affects the initiation and transformation of early-stage tumors into invasive malignancies. A combination of transcription factors, growth factors, signaling pathways, and epigenetic regulations affect the thyroid cell migration and EMT process. MicroRNAs (miRNAs) are important molecular factors involved in tumor metastasis by regulation of EMT-activating signaling pathways. Various miRNAs are involved in the signaling pathways associated with TC metastasis which can be used as diagnostic and therapeutic biomarkers. Since, the miRNAs are sensitive, specific, and non-invasive, they can be suggested as efficient and optimal biomarkers of tumor invasion and metastasis. In the present review, we have summarized all of the miRNAs which have been significantly involved in thyroid tumor cells migration and invasion. We also categorized all of the reported miRNAs based on their cellular processes to clarify the molecular role of miRNAs during thyroid tumor cell migration and invasion. This review paves the way of introducing a non-invasive diagnostic and prognostic panel of miRNAs in aggressive and metastatic TC patients. BioMed Central 2022-06-04 /pmc/articles/PMC9167543/ /pubmed/35659780 http://dx.doi.org/10.1186/s40364-022-00382-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hamidi, Amir Abbas
Taghehchian, Negin
Basirat, Zahra
Zangouei, Amir Sadra
Moghbeli, Meysam
MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title_full MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title_fullStr MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title_full_unstemmed MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title_short MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
title_sort micrornas as the critical regulators of cell migration and invasion in thyroid cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167543/
https://www.ncbi.nlm.nih.gov/pubmed/35659780
http://dx.doi.org/10.1186/s40364-022-00382-4
work_keys_str_mv AT hamidiamirabbas micrornasasthecriticalregulatorsofcellmigrationandinvasioninthyroidcancer
AT taghehchiannegin micrornasasthecriticalregulatorsofcellmigrationandinvasioninthyroidcancer
AT basiratzahra micrornasasthecriticalregulatorsofcellmigrationandinvasioninthyroidcancer
AT zangoueiamirsadra micrornasasthecriticalregulatorsofcellmigrationandinvasioninthyroidcancer
AT moghbelimeysam micrornasasthecriticalregulatorsofcellmigrationandinvasioninthyroidcancer