Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

BACKGROUND: Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron. N501Y in the receptor-binding domain (RBD) of Spike protein is the key mutation dictating the mouse infectivity, on which the nei...

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Detalles Bibliográficos
Autores principales: Zhu, Yichao, Zhou, Wenzhao, Niu, Zubiao, Sun, Jiayi, Zhang, Zhengrong, Li, Qinqin, Zheng, You, Wang, Chenxi, Gao, Lihua, Sun, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167559/
https://www.ncbi.nlm.nih.gov/pubmed/35658928
http://dx.doi.org/10.1186/s13062-022-00325-x

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