Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report

Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermo...

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Autores principales: Tanaka, Ryota, Matsumoto, Asami, Tatsuta, Ryosuke, Ando, Tadasuke, Shin, Toshitaka, Mimata, Hiromitsu, Itoh, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167663/
https://www.ncbi.nlm.nih.gov/pubmed/35677857
http://dx.doi.org/10.1002/ccr3.5914
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author Tanaka, Ryota
Matsumoto, Asami
Tatsuta, Ryosuke
Ando, Tadasuke
Shin, Toshitaka
Mimata, Hiromitsu
Itoh, Hiroki
author_facet Tanaka, Ryota
Matsumoto, Asami
Tatsuta, Ryosuke
Ando, Tadasuke
Shin, Toshitaka
Mimata, Hiromitsu
Itoh, Hiroki
author_sort Tanaka, Ryota
collection PubMed
description Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.
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spelling pubmed-91676632022-06-07 Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report Tanaka, Ryota Matsumoto, Asami Tatsuta, Ryosuke Ando, Tadasuke Shin, Toshitaka Mimata, Hiromitsu Itoh, Hiroki Clin Case Rep Case Reports Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved. John Wiley and Sons Inc. 2022-06-05 /pmc/articles/PMC9167663/ /pubmed/35677857 http://dx.doi.org/10.1002/ccr3.5914 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Tanaka, Ryota
Matsumoto, Asami
Tatsuta, Ryosuke
Ando, Tadasuke
Shin, Toshitaka
Mimata, Hiromitsu
Itoh, Hiroki
Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title_full Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title_fullStr Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title_full_unstemmed Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title_short Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
title_sort sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with crohn's disease: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167663/
https://www.ncbi.nlm.nih.gov/pubmed/35677857
http://dx.doi.org/10.1002/ccr3.5914
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