Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials

BACKGROUND: SOBERANA 02 is a COVID-19 vaccine based on SARS-CoV-2 recombinant RBD conjugated to tetanus toxoid (TT). SOBERANA Plus antigen is dimeric-RBD. Here we report safety and immunogenicity from phase I and IIa clinical trials using two-doses of SOBERANA 02 and three-doses (homologous) or hete...

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Detalles Bibliográficos
Autores principales: Eugenia-Toledo-Romaní, María, Verdecia-Sánchez, Leslyhana, Rodríguez-González, Meiby, Rodríguez-Noda, Laura, Valenzuela-Silva, Carmen, Paredes-Moreno, Beatriz, Sánchez-Ramírez, Belinda, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Bergado-Baez, Gretchen, Pi-Estopiñán, Franciscary, Cruz-Sui, Otto, Fraga-Quintero, Anitza, García-Montero, Majela, Palenzuela-Díaz, Ariel, Baró-Román, Gerardo, Mendoza-Hernández, Ivis, Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, Ramírez Gonzalez, Ubel, García-Vega, Yanelda, Pérez-Massón, Beatriz, Guang-Wu-Chen, Boggiano-Ayo, Tammy, Ojito-Magaz, Eduardo, Rivera, Daniel G., Valdés-Balbín, Yury, García-Rivera, Dagmar, Vérez-Bencomo, Vicente, Gómez-Maceo, Yanet, Reyes-Matienzo, Radamet, Manuel Coviella-Artime, José, Morffi-Cinta, Irania, Martínez-Pérez, Marisel, Castillo-Quintana, Ismavy, Garcés-Hechavarría, Aniurka, Valera-Fernández, Rodrigo, Martínez-Bedoya, Dayle, Garrido-Arteaga, Raine, Cardoso-SanJorge, Félix, Quintero Moreno, Lauren, Ontivero-Pino, Ivis, Teresa Pérez-Guevara, María, Morales-García, Marilin, Noa-Romero, Enrique, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, Rojas, Gertrudis, Tundidor, Yaima, García-López, Elena, Muñoz-Morejon, Yaima, Galano-Frutos, Evelyn, Rodríguez-Alvarez, Julián, Arteaga, Amaylid, Medina Nápoles, Maite, Espi Ávila, Jennifer, Fontanies Fernández, Marcos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167831/
https://www.ncbi.nlm.nih.gov/pubmed/35691871
http://dx.doi.org/10.1016/j.vaccine.2022.05.082

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