Cargando…

Integrated Analysis Reveals the Gut Microbial Metabolite TMAO Promotes Inflammatory Hepatocellular Carcinoma by Upregulating POSTN

Liver cancer has a high mortality rate. Chronic inflammation is one of the leading causes of hepatocellular carcinoma. Recent studies suggested high levels of trimethylamine N-oxide (TMAO) may correlate with increased risk of inflammatory-induced liver cancer. However, the mechanisms by which TMAO p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yonglin, Rong, Xingyu, Pan, Miaomiao, Wang, Tongyao, Yang, Hao, Chen, Xiejiu, Xiao, Zhenming, Zhao, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167932/ https://www.ncbi.nlm.nih.gov/pubmed/35676936 http://dx.doi.org/10.3389/fcell.2022.840171

Ejemplares similares

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model
por: Shen, Xiaopeng, et al.
Publicado: (2021)

Knockdown of POSTN Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells From Patients With Steroid-Induced Osteonecrosis
por: Han, Lizhi, et al.
Publicado: (2020)

HIF-1α Regulates Osteogenesis of Periosteum-Derived Stem Cells Under Hypoxia Conditions via Modulating POSTN Expression
por: Zhuang, Yu, et al.
Publicado: (2022)

Circular RNA POSTN Promotes Myocardial Infarction-Induced Myocardial Injury and Cardiac Remodeling by Regulating miR-96-5p/BNIP3 Axis
por: Cheng, Nan, et al.
Publicado: (2021)

TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4
por: Liu, Xiang, et al.
Publicado: (2022)

The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer
por: Sui, Yue, et al.
Publicado: (2021)

Are Metabolites From the Gut Microbiota Capable of Regulating Epigenetic Mechanisms in the Human Parasite Entamoeba histolytica?
por: Sarid, Lotem, et al.
Publicado: (2022)

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin
por: Wang, Miaomiao, et al.
Publicado: (2021)

Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition
por: Liu, Yunzi, et al.
Publicado: (2021)

Effect of Quercetin on Lipids Metabolism Through Modulating the Gut Microbial and AMPK/PPAR Signaling Pathway in Broilers
por: Wang, Mi, et al.
Publicado: (2021)

Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
por: Iyer, Krishna, et al.
Publicado: (2023)

M(6)A-Mediated Upregulation of LINC00106 Promotes Stemness and Metastasis Properties of Hepatocellular Carcinoma via Sponging Let7f
por: Liang, Wenjin, et al.
Publicado: (2021)

Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
por: Querio, Giulia, et al.
Publicado: (2023)

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives
por: Pan, Fan, et al.
Publicado: (2021)

TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
por: Canyelles, Marina, et al.
Publicado: (2022)

The Critical Role of Ferroptosis in Hepatocellular Carcinoma
por: Pan, Fan, et al.
Publicado: (2022)

Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma
por: Sivasudhan, Enakshi, et al.
Publicado: (2021)

Treacle is Upregulated in Cancer and Correlates With Poor Prognosis
por: Oxe, Kezia Catharina, et al.
Publicado: (2022)

Plasma Metabolomic and Intestinal Microbial Analyses of Patients With Severe Aplastic Anemia
por: Shao, Yuanyuan, et al.
Publicado: (2021)

Peroxisomal Metabolite and Cofactor Transport in Humans
por: Chornyi, Serhii, et al.
Publicado: (2021)

Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis
por: Wu, Zeng-Hong, et al.
Publicado: (2022)

PARP1 Upregulation in Recurrent Oral Cancer and Treatment Resistance
por: Wang, Feifei, et al.
Publicado: (2022)

Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment
por: Kervin, Troy A., et al.
Publicado: (2021)

The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
por: Zhao, Siqi, et al.
Publicado: (2022)

An update on the biological characteristics and functions of tuft cells in the gut
por: Du, Yixuan, et al.
Publicado: (2023)

ER-Phagy and Microbial Infection
por: Li, Jiahui, et al.
Publicado: (2021)

Crosstalk between liver macrophages and gut microbiota: An important component of inflammation-associated liver diseases
por: Zhou, Ziyuan, et al.
Publicado: (2022)

Cerebral Ischemia-Reperfusion Is Associated With Upregulation of Cofilin-1 in the Motor Cortex
por: Xu, Ming-Shu, et al.
Publicado: (2021)

Upregulation of Fibrinogen-Like 1 Expression Contributes to Reducing the Progression of Preeclampsia
por: Cheng, Tsung-Lin, et al.
Publicado: (2021)

PRSS1 Upregulation Predicts Platinum Resistance in Ovarian Cancer Patients
por: Xing, Linan, et al.
Publicado: (2021)

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
por: Ullrich, Simon, et al.
Publicado: (2023)

Fine-tuning of regulatory T cells is indispensable for the metabolic steatosis-related hepatocellular carcinoma: A review
por: Riaz, Farooq, et al.
Publicado: (2022)

Identification of novel lactate metabolism signatures and molecular subtypes for prognosis in hepatocellular carcinoma
por: Guan, Qiutong, et al.
Publicado: (2022)

Upregulation of Parkin Accelerates Osteoblastic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells and Bone Regeneration by Enhancing Autophagy and β-Catenin Signaling
por: Zhang, Wei, et al.
Publicado: (2020)

Lymphatic Absorption of Microbial Plasmalogens in Rats
por: Sato, Nana, et al.
Publicado: (2022)

Potential of gut microbiota for lipopolysaccharide biosynthesis in European women with type 2 diabetes based on metagenome
por: Dong, Ying, et al.
Publicado: (2022)

Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation
por: Streletskaia, Alena Y., et al.
Publicado: (2020)

Elevated Hydrostatic Pressure Causes Retinal Degeneration Through Upregulating Lipocalin-2
por: Yoneshige, Azusa, et al.
Publicado: (2021)

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress
por: Govindarajulu, Manoj, et al.
Publicado: (2020)

Association Between Frailty and Gut Microbiota Metabolite TMAO in Older People With Cardiovascular Disease
por: He, Wei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3to4446fe17l9uiceh3e6o4slc