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Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?

A close inter-relationship between mobility and cognition is reported in older adults, with improvements in gait performance noticeable after cognitive remediation in frail individuals. The aim of this study was to evaluate the efficacy of computerized cognitive training (CCT) on mobility in healthy...

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Autores principales: Marusic, Uros, Verghese, Joe, Mahoney, Jeannette R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168002/
https://www.ncbi.nlm.nih.gov/pubmed/35677205
http://dx.doi.org/10.3389/fnagi.2022.845825
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author Marusic, Uros
Verghese, Joe
Mahoney, Jeannette R.
author_facet Marusic, Uros
Verghese, Joe
Mahoney, Jeannette R.
author_sort Marusic, Uros
collection PubMed
description A close inter-relationship between mobility and cognition is reported in older adults, with improvements in gait performance noticeable after cognitive remediation in frail individuals. The aim of this study was to evaluate the efficacy of computerized cognitive training (CCT) on mobility in healthy, independently living older adults, and to determine whether CCT is associated with changes in neural activation for mobility-related brain processes. Using a randomized single-blind control design, sixty-three non-demented adults age 60 y and older (mean age = 67 y; 76% female, mean Montreal Cognitive Assessment [MoCA] score = 27) were recruited from a local Senior Activity Center. Participants were randomly assigned to either a 2-month CCT program (8 weeks, 3x/week, 40 min/session) or a wait-list control group. Primary outcome was self-selected gait speed during single- and dual-task walking. Secondary outcome was executive function on Trail Making Test (TMT), Part B. Neural activity was assessed via electroencephalography/event-related potentials (EEG/ERPs) targeting lower-limb performance. Results from a linear mixed effect model, adjusted for baseline MoCA score, age, gender, and study completion revealed that compared to controls, CCT improved gait speed during the dual-task (p = 0.008) but not during the single-task walking condition (p = 0.057). CCT also improved executive function (p = 0.024). Further, shorter foot reaction time responses (p = 0.019) were found with enhanced neural activation over sensorimotor areas, with shorter ERP latencies during the P2 component (p = 0.008) and enhanced motor responses (p = 0.009) also evident in the CCT group after the intervention. Overall, the electrophysiological findings suggest possible neural adaptations that could explain improvements in mobility and executive functions associated with CCT in healthy older adults.
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spelling pubmed-91680022022-06-07 Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation? Marusic, Uros Verghese, Joe Mahoney, Jeannette R. Front Aging Neurosci Aging Neuroscience A close inter-relationship between mobility and cognition is reported in older adults, with improvements in gait performance noticeable after cognitive remediation in frail individuals. The aim of this study was to evaluate the efficacy of computerized cognitive training (CCT) on mobility in healthy, independently living older adults, and to determine whether CCT is associated with changes in neural activation for mobility-related brain processes. Using a randomized single-blind control design, sixty-three non-demented adults age 60 y and older (mean age = 67 y; 76% female, mean Montreal Cognitive Assessment [MoCA] score = 27) were recruited from a local Senior Activity Center. Participants were randomly assigned to either a 2-month CCT program (8 weeks, 3x/week, 40 min/session) or a wait-list control group. Primary outcome was self-selected gait speed during single- and dual-task walking. Secondary outcome was executive function on Trail Making Test (TMT), Part B. Neural activity was assessed via electroencephalography/event-related potentials (EEG/ERPs) targeting lower-limb performance. Results from a linear mixed effect model, adjusted for baseline MoCA score, age, gender, and study completion revealed that compared to controls, CCT improved gait speed during the dual-task (p = 0.008) but not during the single-task walking condition (p = 0.057). CCT also improved executive function (p = 0.024). Further, shorter foot reaction time responses (p = 0.019) were found with enhanced neural activation over sensorimotor areas, with shorter ERP latencies during the P2 component (p = 0.008) and enhanced motor responses (p = 0.009) also evident in the CCT group after the intervention. Overall, the electrophysiological findings suggest possible neural adaptations that could explain improvements in mobility and executive functions associated with CCT in healthy older adults. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9168002/ /pubmed/35677205 http://dx.doi.org/10.3389/fnagi.2022.845825 Text en Copyright © 2022 Marusic, Verghese and Mahoney. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Marusic, Uros
Verghese, Joe
Mahoney, Jeannette R.
Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title_full Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title_fullStr Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title_full_unstemmed Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title_short Does Cognitive Training Improve Mobility, Enhance Cognition, and Promote Neural Activation?
title_sort does cognitive training improve mobility, enhance cognition, and promote neural activation?
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168002/
https://www.ncbi.nlm.nih.gov/pubmed/35677205
http://dx.doi.org/10.3389/fnagi.2022.845825
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