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Conjugation with 8-arm PEG and CRM(197) enhances the immunogenicity of SARS-CoV-2 ORF8 protein

Safe and effective vaccines are urgently needed to combat the COVID-19 pandemic. However, the SARS-CoV-2 variants raise concerns about the effectiveness of vaccines. As a SARS-CoV-2 antigen target, ORF8 strongly inhibits the IFN-β and NF-κB-responsive promoter, and can be potentially used for the de...

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Detalles Bibliográficos
Autores principales:	Tang, Xiaozhao, Yu, Weili, Shen, Lijuan, Qi, Jinming, Hu, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168007/ https://www.ncbi.nlm.nih.gov/pubmed/35687905 http://dx.doi.org/10.1016/j.intimp.2022.108922

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