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Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis

The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances m...

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Detalles Bibliográficos
Autores principales: Hawerkamp, H. C., Fahy, C. M. R., Fallon, P. G., Schwartz, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168024/
https://www.ncbi.nlm.nih.gov/pubmed/35677926
http://dx.doi.org/10.1002/ski2.99
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author Hawerkamp, H. C.
Fahy, C. M. R.
Fallon, P. G.
Schwartz, C.
author_facet Hawerkamp, H. C.
Fahy, C. M. R.
Fallon, P. G.
Schwartz, C.
author_sort Hawerkamp, H. C.
collection PubMed
description The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients.
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spelling pubmed-91680242022-06-07 Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis Hawerkamp, H. C. Fahy, C. M. R. Fallon, P. G. Schwartz, C. Skin Health Dis Review Articles The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients. John Wiley and Sons Inc. 2022-02-16 /pmc/articles/PMC9168024/ /pubmed/35677926 http://dx.doi.org/10.1002/ski2.99 Text en © 2022 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Hawerkamp, H. C.
Fahy, C. M. R.
Fallon, P. G.
Schwartz, C.
Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title_full Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title_fullStr Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title_full_unstemmed Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title_short Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
title_sort break on through: the role of innate immunity and barrier defence in atopic dermatitis and psoriasis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168024/
https://www.ncbi.nlm.nih.gov/pubmed/35677926
http://dx.doi.org/10.1002/ski2.99
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