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Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis
The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances m...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168024/ https://www.ncbi.nlm.nih.gov/pubmed/35677926 http://dx.doi.org/10.1002/ski2.99 |
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author | Hawerkamp, H. C. Fahy, C. M. R. Fallon, P. G. Schwartz, C. |
author_facet | Hawerkamp, H. C. Fahy, C. M. R. Fallon, P. G. Schwartz, C. |
author_sort | Hawerkamp, H. C. |
collection | PubMed |
description | The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients. |
format | Online Article Text |
id | pubmed-9168024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91680242022-06-07 Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis Hawerkamp, H. C. Fahy, C. M. R. Fallon, P. G. Schwartz, C. Skin Health Dis Review Articles The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients. John Wiley and Sons Inc. 2022-02-16 /pmc/articles/PMC9168024/ /pubmed/35677926 http://dx.doi.org/10.1002/ski2.99 Text en © 2022 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Hawerkamp, H. C. Fahy, C. M. R. Fallon, P. G. Schwartz, C. Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title | Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title_full | Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title_fullStr | Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title_full_unstemmed | Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title_short | Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
title_sort | break on through: the role of innate immunity and barrier defence in atopic dermatitis and psoriasis |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168024/ https://www.ncbi.nlm.nih.gov/pubmed/35677926 http://dx.doi.org/10.1002/ski2.99 |
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