Roles of Ferroptosis in Cardiovascular Diseases

Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation be...

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Autores principales: Guo, Yuting, Zhang, Wei, Zhou, Xinger, Zhao, Shihao, Wang, Jian, Guo, Yi, Liao, Yichao, Lu, Haihui, Liu, Jie, Cai, Yanbin, Wu, Jiao, Shen, Mingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168067/
https://www.ncbi.nlm.nih.gov/pubmed/35677693
http://dx.doi.org/10.3389/fcvm.2022.911564
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author Guo, Yuting
Zhang, Wei
Zhou, Xinger
Zhao, Shihao
Wang, Jian
Guo, Yi
Liao, Yichao
Lu, Haihui
Liu, Jie
Cai, Yanbin
Wu, Jiao
Shen, Mingzhi
author_facet Guo, Yuting
Zhang, Wei
Zhou, Xinger
Zhao, Shihao
Wang, Jian
Guo, Yi
Liao, Yichao
Lu, Haihui
Liu, Jie
Cai, Yanbin
Wu, Jiao
Shen, Mingzhi
author_sort Guo, Yuting
collection PubMed
description Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation between ferroptosis and various cardiovascular diseases such as atherosclerosis, acute myocardial infarction, ischemia/reperfusion injury, cardiomyopathy, and heart failure. Herein, we will review the contributions of ferroptosis to multiple cardiovascular diseases and the related targets. Further, we discuss the potential ferroptosis-targeting strategies for treating different cardiovascular diseases.
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spelling pubmed-91680672022-06-07 Roles of Ferroptosis in Cardiovascular Diseases Guo, Yuting Zhang, Wei Zhou, Xinger Zhao, Shihao Wang, Jian Guo, Yi Liao, Yichao Lu, Haihui Liu, Jie Cai, Yanbin Wu, Jiao Shen, Mingzhi Front Cardiovasc Med Cardiovascular Medicine Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation between ferroptosis and various cardiovascular diseases such as atherosclerosis, acute myocardial infarction, ischemia/reperfusion injury, cardiomyopathy, and heart failure. Herein, we will review the contributions of ferroptosis to multiple cardiovascular diseases and the related targets. Further, we discuss the potential ferroptosis-targeting strategies for treating different cardiovascular diseases. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9168067/ /pubmed/35677693 http://dx.doi.org/10.3389/fcvm.2022.911564 Text en Copyright © 2022 Guo, Zhang, Zhou, Zhao, Wang, Guo, Liao, Lu, Liu, Cai, Wu and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Guo, Yuting
Zhang, Wei
Zhou, Xinger
Zhao, Shihao
Wang, Jian
Guo, Yi
Liao, Yichao
Lu, Haihui
Liu, Jie
Cai, Yanbin
Wu, Jiao
Shen, Mingzhi
Roles of Ferroptosis in Cardiovascular Diseases
title Roles of Ferroptosis in Cardiovascular Diseases
title_full Roles of Ferroptosis in Cardiovascular Diseases
title_fullStr Roles of Ferroptosis in Cardiovascular Diseases
title_full_unstemmed Roles of Ferroptosis in Cardiovascular Diseases
title_short Roles of Ferroptosis in Cardiovascular Diseases
title_sort roles of ferroptosis in cardiovascular diseases
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168067/
https://www.ncbi.nlm.nih.gov/pubmed/35677693
http://dx.doi.org/10.3389/fcvm.2022.911564
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