Cargando…

Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation

Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the antiproliferative activity and mechanism of Rh4 against CRC in vivo and in vitro. The CRC xenograft model showed that Rh4 inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yingchao, Pi, Dajin, Chen, Yiliu, Zuo, Qian, Zhou, Shuyao, Ouyang, Mingzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168088/ https://www.ncbi.nlm.nih.gov/pubmed/35677385 http://dx.doi.org/10.1155/2022/6177553

Ejemplares similares

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells: Ginsenoside Rh3 has anti-colorectal cancer properties
por: Wu, Yingchao, et al.
Publicado: (2023)

Yiqi Chutan Formula Reverses Cisplatin-Induced Apoptosis and Ferroptosis of Skeletal Muscle by Alleviating Oxidative Stress
por: Wu, Yingchao, et al.
Publicado: (2023)

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice
por: Wu, Yingchao, et al.
Publicado: (2022)

Luteolin induces pyroptosis in HT-29 cells by activating the Caspase1/Gasdermin D signalling pathway
por: Chen, Yiliu, et al.
Publicado: (2022)

Deciphering the Molecular Mechanism of Yifei-Sanjie Pill in Cancer-Related Fatigue
por: Wu, Yingchao, et al.
Publicado: (2023)

Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy
por: Yang, Zhiqing, et al.
Publicado: (2016)

Ginsenoside Rh2 inhibits breast cancer cell growth viaERβ-TNFα pathway: Ginsenoside Rh2 inhibits breast cancer cell growth via ERβ-TNFα
por: Peng, Kunjian, et al.
Publicado: (2022)

The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
por: Lin, Yingjia, et al.
Publicado: (2017)

Ginsenoside Rh2 inhibits thyroid cancer cell migration and proliferation via activation of miR-524-5p
por: Jiang, Shan, et al.
Publicado: (2020)

Ginsenoside Rh2 activates α-catenin phosphorylation to inhibit lung cancer cell proliferation and invasion
por: Zhang, Guodong, et al.
Publicado: (2020)

Ginsenoside Rh1 inhibits colorectal cancer cell migration and invasion in vitro and tumor growth in vivo
por: Lyu, Xi, et al.
Publicado: (2019)

A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy
por: Yang, Jing, et al.
Publicado: (2023)

20(S)-Ginsenoside Rh2 Induce the Apoptosis and Autophagy in U937 and K562 Cells
por: Zhuang, Jianjian, et al.
Publicado: (2018)

Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation
por: Wang, Jiawen, et al.
Publicado: (2020)

Kai-Xin-San Attenuates Doxorubicin-Induced Cognitive Impairment by Reducing Inflammation, Oxidative Stress, and Neural Degeneration in 4T1 Breast Cancer Mice
por: Lyu, Wenjiao, et al.
Publicado: (2021)

20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo
por: Zhang, Haibo, et al.
Publicado: (2022)

Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling
por: Zhang, Yan, et al.
Publicado: (2022)

Ginsenoside Rh1 Alleviates HK-2 Apoptosis by Inhibiting ROS and the JNK/p53 Pathways
por: Yang, Qi, et al.
Publicado: (2020)

Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
por: Lee, Hyunkyung, et al.
Publicado: (2018)

Ginsenoside Rh2 inhibits human A172 glioma cell proliferation and induces cell cycle arrest status via modulating Akt signaling pathway
por: Li, Kai-Fei, et al.
Publicado: (2018)

Induction of apoptosis in prostate cancer by ginsenoside Rh2
por: Tong-Lin Wu, Tony, et al.
Publicado: (2018)

Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells
por: Xia, Ting, et al.
Publicado: (2016)

Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells
por: Xia, Ting, et al.
Publicado: (2017)

Ginsenoside Rh3 Inhibits Lung Cancer Metastasis by Targeting Extracellular Signal-Regulated Kinase: A Network Pharmacology Study
por: Xue, Xiaodan, et al.
Publicado: (2022)

Transcriptome Analysis of the Anti-Proliferative Effects of Ginsenoside Rh3 on HCT116 Colorectal Cancer Cells
por: Teng, Siying, et al.
Publicado: (2022)

SPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis
por: Hu, Bang-li, et al.
Publicado: (2023)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation
por: Chen, Fang, et al.
Publicado: (2016)

Increased antitumor efficacy of ginsenoside Rh(2) via mixed micelles: in vivo and in vitro evaluation
por: Xia, Xiaojing, et al.
Publicado: (2020)

Ginsenoside Rh2 Suppresses Metastasis and Growth of Colon Cancer via miR-491
por: Wei, Wene, et al.
Publicado: (2021)

Biotransformation of ginsenosides Rb(1), Rg(3 )and Rh(2 )in rat gastrointestinal tracts
por: Qian, Tianxiu, et al.
Publicado: (2010)

(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2
por: Wang, Yu-Shi, et al.
Publicado: (2021)

20(S)-ginsenoside Rh2 as agent for the treatment of LMN-CRC via regulating epithelial–mesenchymal transition
por: Yuan, Yihang, et al.
Publicado: (2020)

Neuroprotective effects of ginsenosides Rh(1 )and Rg(2 )on neuronal cells
por: Li, Xiao-Fan, et al.
Publicado: (2011)

Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2
por: Popov, Alexander, et al.
Publicado: (2022)

Structure Modification of Ginsenoside Rh(2) and Cytostatic Activity on Cancer Cells
por: Liang, Junyu, et al.
Publicado: (2023)

Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation
por: Mathiyalagan, Ramya, et al.
Publicado: (2019)

Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis: Ginsenoside Rh2 inhibits colon cancer growth via miR-150-3p/SRCIN1/Wnt
por: Li, Shipeng, et al.
Publicado: (2023)

Comparative Pharmacokinetics of Ginsenoside Rg(3) and Ginsenoside Rh(2) after Oral Administration of Ginsenoside Rg(3) in Normal and Walker 256 Tumor-bearing Rats
por: Fan, He, et al.
Publicado: (2016)

Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer
por: Wang, Xinyuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6m324u2143ruqe5lf8grcjqchd