Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities. In recent years, a large number of studies have described th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yuanwei, Tang, Danting, Li, Xiaoqi, Xie, Xiaoli, Ye, Yufu, Wang, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168125/
https://www.ncbi.nlm.nih.gov/pubmed/35677161
http://dx.doi.org/10.3389/fonc.2022.889034
_version_ 1784720931766140928
author Shi, Yuanwei
Tang, Danting
Li, Xiaoqi
Xie, Xiaoli
Ye, Yufu
Wang, Lijuan
author_facet Shi, Yuanwei
Tang, Danting
Li, Xiaoqi
Xie, Xiaoli
Ye, Yufu
Wang, Lijuan
author_sort Shi, Yuanwei
collection PubMed
description The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities. In recent years, a large number of studies have described the expression and correlation of galectins in different tumors. Each member of the family plays a vital role in tumor growth, progression, angiogenesis, adhesion, and tumor immune escape. Studies on the roles of galectins in lymphoma have mainly involved galectin-1, -3, -7, and -9. The results suggest that galectins may become novel targets for precise tumor treatment. This article reviews current research progress regarding galectins in lymphoma and provides new ideas for exploring them as novel targets for treating lymphoma and other important medical issues.
format Online
Article
Text
id pubmed-9168125
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91681252022-06-07 Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy? Shi, Yuanwei Tang, Danting Li, Xiaoqi Xie, Xiaoli Ye, Yufu Wang, Lijuan Front Oncol Oncology The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities. In recent years, a large number of studies have described the expression and correlation of galectins in different tumors. Each member of the family plays a vital role in tumor growth, progression, angiogenesis, adhesion, and tumor immune escape. Studies on the roles of galectins in lymphoma have mainly involved galectin-1, -3, -7, and -9. The results suggest that galectins may become novel targets for precise tumor treatment. This article reviews current research progress regarding galectins in lymphoma and provides new ideas for exploring them as novel targets for treating lymphoma and other important medical issues. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9168125/ /pubmed/35677161 http://dx.doi.org/10.3389/fonc.2022.889034 Text en Copyright © 2022 Shi, Tang, Li, Xie, Ye and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shi, Yuanwei
Tang, Danting
Li, Xiaoqi
Xie, Xiaoli
Ye, Yufu
Wang, Lijuan
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title_full Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title_fullStr Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title_full_unstemmed Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title_short Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
title_sort galectin family members: emerging novel targets for lymphoma therapy?
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168125/
https://www.ncbi.nlm.nih.gov/pubmed/35677161
http://dx.doi.org/10.3389/fonc.2022.889034
work_keys_str_mv AT shiyuanwei galectinfamilymembersemergingnoveltargetsforlymphomatherapy
AT tangdanting galectinfamilymembersemergingnoveltargetsforlymphomatherapy
AT lixiaoqi galectinfamilymembersemergingnoveltargetsforlymphomatherapy
AT xiexiaoli galectinfamilymembersemergingnoveltargetsforlymphomatherapy
AT yeyufu galectinfamilymembersemergingnoveltargetsforlymphomatherapy
AT wanglijuan galectinfamilymembersemergingnoveltargetsforlymphomatherapy

Ejemplares similares