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Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment

Development of non-invasive and in utero placenta imaging techniques can potentially identify biomarkers of placental health. Correlative imaging using multiple multiscale modalities is particularly important to advance the understanding of placenta structure, function and their relationship. The ob...

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Autores principales: Deeba, Farah, Hu, Ricky, Lessoway, Victoria, Terry, Jefferson, Pugash, Denise, Mayer, Chantal, Hutcheon, Jennifer, Salcudean, Septimiu, Rohling, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168134/
https://www.ncbi.nlm.nih.gov/pubmed/35677846
http://dx.doi.org/10.1016/j.mex.2022.101738
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author Deeba, Farah
Hu, Ricky
Lessoway, Victoria
Terry, Jefferson
Pugash, Denise
Mayer, Chantal
Hutcheon, Jennifer
Salcudean, Septimiu
Rohling, Robert
author_facet Deeba, Farah
Hu, Ricky
Lessoway, Victoria
Terry, Jefferson
Pugash, Denise
Mayer, Chantal
Hutcheon, Jennifer
Salcudean, Septimiu
Rohling, Robert
author_sort Deeba, Farah
collection PubMed
description Development of non-invasive and in utero placenta imaging techniques can potentially identify biomarkers of placental health. Correlative imaging using multiple multiscale modalities is particularly important to advance the understanding of placenta structure, function and their relationship. The objective of the project SWAVE 2.0 was to understand human placental structure and function and thereby identify quantifiable measures of placental health using a multimodal correlative approach. In this paper, we present a multimodal image acquisition protocol designed to acquire and align data from ex vivo placenta specimens derived from both healthy and complicated pregnancies. Qualitative and quantitative validation of the alignment method were performed. The qualitative analysis showed good correlation between findings in the MRI, ultrasound and histopathology images. The proposed protocol would enable future studies on comprehensive analysis of placental anatomy, function and their relationship. ● An overview of a novel multimodal placental image acquisition protocol is presented. ● A co-registration method using surface markers and external fiducials is described. ● A preliminary correlative imaging analysis for a placenta specimen is presented.
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spelling pubmed-91681342022-06-07 Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment Deeba, Farah Hu, Ricky Lessoway, Victoria Terry, Jefferson Pugash, Denise Mayer, Chantal Hutcheon, Jennifer Salcudean, Septimiu Rohling, Robert MethodsX Method Article Development of non-invasive and in utero placenta imaging techniques can potentially identify biomarkers of placental health. Correlative imaging using multiple multiscale modalities is particularly important to advance the understanding of placenta structure, function and their relationship. The objective of the project SWAVE 2.0 was to understand human placental structure and function and thereby identify quantifiable measures of placental health using a multimodal correlative approach. In this paper, we present a multimodal image acquisition protocol designed to acquire and align data from ex vivo placenta specimens derived from both healthy and complicated pregnancies. Qualitative and quantitative validation of the alignment method were performed. The qualitative analysis showed good correlation between findings in the MRI, ultrasound and histopathology images. The proposed protocol would enable future studies on comprehensive analysis of placental anatomy, function and their relationship. ● An overview of a novel multimodal placental image acquisition protocol is presented. ● A co-registration method using surface markers and external fiducials is described. ● A preliminary correlative imaging analysis for a placenta specimen is presented. Elsevier 2022-05-23 /pmc/articles/PMC9168134/ /pubmed/35677846 http://dx.doi.org/10.1016/j.mex.2022.101738 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Method Article
Deeba, Farah
Hu, Ricky
Lessoway, Victoria
Terry, Jefferson
Pugash, Denise
Mayer, Chantal
Hutcheon, Jennifer
Salcudean, Septimiu
Rohling, Robert
Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title_full Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title_fullStr Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title_full_unstemmed Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title_short Project SWAVE 2.0: An overview of the study design for multimodal placental image acquisition and alignment
title_sort project swave 2.0: an overview of the study design for multimodal placental image acquisition and alignment
topic Method Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168134/
https://www.ncbi.nlm.nih.gov/pubmed/35677846
http://dx.doi.org/10.1016/j.mex.2022.101738
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