Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain

Type-2 cannabinoid receptors (CB2, encoded by the Cnr2 gene) are mainly expressed in immune cells, and CB2 agonists normally have no analgesic effect. However, nerve injury upregulates CB2 in the dorsal root ganglion (DRG), following which CB2 stimulation reduces neuropathic pain. It is unclear how...

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Detalles Bibliográficos
Autores principales: Ghosh, Krishna, Zhang, Guang-Fen, Chen, Hong, Chen, Shao-Rui, Pan, Hui-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168157/
https://www.ncbi.nlm.nih.gov/pubmed/35500651
http://dx.doi.org/10.1016/j.jbc.2022.101999

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