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A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer

The redox regulator NRF2 is hyperactivated in a large percentage of non-small cell lung cancer (NSCLC) cases, which is associated with chemotherapy and radiation resistance. To identify redox vulnerabilities for KEAP1/NRF2 mutant NSCLC, we conducted a CRISPR-Cas9-based negative selection screen for...

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Detalles Bibliográficos
Autores principales:	Jiang, Chang, P. Ward, Nathan, Prieto-Farigua, Nicolas, Kang, Yun Pyo, Thalakola, Anish, Teng, Mingxiang, M. DeNicola, Gina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168196/ https://www.ncbi.nlm.nih.gov/pubmed/35667246 http://dx.doi.org/10.1016/j.redox.2022.102358

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