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Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains

Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional...

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Autores principales: Xia, Lin, Zhang, Chen, Su, Kaiming, Fan, Jiangang, Niu, Yuguang, Yu, Yafeng, Chai, Renjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168218/
https://www.ncbi.nlm.nih.gov/pubmed/35677297
http://dx.doi.org/10.3389/fbioe.2022.895107
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author Xia, Lin
Zhang, Chen
Su, Kaiming
Fan, Jiangang
Niu, Yuguang
Yu, Yafeng
Chai, Renjie
author_facet Xia, Lin
Zhang, Chen
Su, Kaiming
Fan, Jiangang
Niu, Yuguang
Yu, Yafeng
Chai, Renjie
author_sort Xia, Lin
collection PubMed
description Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional connections. So the oriented growth of the newly derived neurons is a key factor in neural stem cell–based nerve regeneration. Nowadays, various biomaterials have been applied to assist in the oriented growth of neural stem cell–derived neurons. However, among these biomaterials, the magnetic materials applied in guiding the neuronal growth are still fewer than the other materials, such as the fibers. So in this work, we developed the magnetic nanochains to guide the oriented growth of neural stem cell–derived neurons. With the guidance of the magnetic nanochains, the seeded neural stem cells exhibited a good arrangement, and the neural stem cell–derived neurons showed well-oriented growth with the orientation of the nanochains. We anticipated that the magnetic nanochains would have huge potential in stem cell–based nerve regeneration.
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spelling pubmed-91682182022-06-07 Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains Xia, Lin Zhang, Chen Su, Kaiming Fan, Jiangang Niu, Yuguang Yu, Yafeng Chai, Renjie Front Bioeng Biotechnol Bioengineering and Biotechnology Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional connections. So the oriented growth of the newly derived neurons is a key factor in neural stem cell–based nerve regeneration. Nowadays, various biomaterials have been applied to assist in the oriented growth of neural stem cell–derived neurons. However, among these biomaterials, the magnetic materials applied in guiding the neuronal growth are still fewer than the other materials, such as the fibers. So in this work, we developed the magnetic nanochains to guide the oriented growth of neural stem cell–derived neurons. With the guidance of the magnetic nanochains, the seeded neural stem cells exhibited a good arrangement, and the neural stem cell–derived neurons showed well-oriented growth with the orientation of the nanochains. We anticipated that the magnetic nanochains would have huge potential in stem cell–based nerve regeneration. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9168218/ /pubmed/35677297 http://dx.doi.org/10.3389/fbioe.2022.895107 Text en Copyright © 2022 Xia, Zhang, Su, Fan, Niu, Yu and Chai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Xia, Lin
Zhang, Chen
Su, Kaiming
Fan, Jiangang
Niu, Yuguang
Yu, Yafeng
Chai, Renjie
Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title_full Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title_fullStr Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title_full_unstemmed Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title_short Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains
title_sort oriented growth of neural stem cell–derived neurons regulated by magnetic nanochains
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168218/
https://www.ncbi.nlm.nih.gov/pubmed/35677297
http://dx.doi.org/10.3389/fbioe.2022.895107
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