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Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center

BACKGROUND AND OBJECTIVES: Insertion of an External Ventricular Drain (EVD) is a common and important lifesaving procedure that can lead to morbidity and mortality. This study was conducted to assess the infection rate, risk factors, causative organisms, and outcome of EVDs. MATERIALS AND METHODS: A...

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Autores principales: Mehreen, Syeda Fakiha, Padmaja, Kanne, Sudhaharan, Sukanya, Teja, Vijay D, Saradhi, Mudumba Vijay, Krishna, Y. Vamsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168257/
https://www.ncbi.nlm.nih.gov/pubmed/35765554
http://dx.doi.org/10.18502/ijm.v14i2.9183
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author Mehreen, Syeda Fakiha
Padmaja, Kanne
Sudhaharan, Sukanya
Teja, Vijay D
Saradhi, Mudumba Vijay
Krishna, Y. Vamsi
author_facet Mehreen, Syeda Fakiha
Padmaja, Kanne
Sudhaharan, Sukanya
Teja, Vijay D
Saradhi, Mudumba Vijay
Krishna, Y. Vamsi
author_sort Mehreen, Syeda Fakiha
collection PubMed
description BACKGROUND AND OBJECTIVES: Insertion of an External Ventricular Drain (EVD) is a common and important lifesaving procedure that can lead to morbidity and mortality. This study was conducted to assess the infection rate, risk factors, causative organisms, and outcome of EVDs. MATERIALS AND METHODS: A prospective study was undertaken in a tertiary care centre from August 1(st) to October 30(th), 2020. Over 192 patients had undergone insertion of EVDs in the neurosurgical intensive care unit. CSF samples were collected in sterile containers and transported to the laboratory. RESULTS: A total of 214 EVDs were inserted in 192 patients for 691 days. The median duration for EVD in situ and the mean time between catheter insertion and onset of infection were 14.5 days and 8 days. EVD related infection rate was 19.4 for 1000 EVD days. The most common risk factor for EVD insertion were tumors (55%) followed by hydrocephalus (40%).We identified 25 patients out of 192 (12%) who had clinical signs and symptoms with deranged CSF counts. A total of 13/25 (52%) specimens were culture positives out of which 10 (76.9%) were Gram negative pathogens and 3 (23%) were Gram positive pathogens and 3/10 (30%) Gram negative pathogens were Multidrug resistant organisms (MDROs). CONCLUSION: It was observed that longer duration of catheter in situ was an important risk factor for EVD-related infections (ERIs) and also higher frequency of CSF sampling. A proper EVD infection prevention and control protocol must be followed in the form of a checklist at the time of EVD insertion.
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spelling pubmed-91682572022-06-27 Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center Mehreen, Syeda Fakiha Padmaja, Kanne Sudhaharan, Sukanya Teja, Vijay D Saradhi, Mudumba Vijay Krishna, Y. Vamsi Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Insertion of an External Ventricular Drain (EVD) is a common and important lifesaving procedure that can lead to morbidity and mortality. This study was conducted to assess the infection rate, risk factors, causative organisms, and outcome of EVDs. MATERIALS AND METHODS: A prospective study was undertaken in a tertiary care centre from August 1(st) to October 30(th), 2020. Over 192 patients had undergone insertion of EVDs in the neurosurgical intensive care unit. CSF samples were collected in sterile containers and transported to the laboratory. RESULTS: A total of 214 EVDs were inserted in 192 patients for 691 days. The median duration for EVD in situ and the mean time between catheter insertion and onset of infection were 14.5 days and 8 days. EVD related infection rate was 19.4 for 1000 EVD days. The most common risk factor for EVD insertion were tumors (55%) followed by hydrocephalus (40%).We identified 25 patients out of 192 (12%) who had clinical signs and symptoms with deranged CSF counts. A total of 13/25 (52%) specimens were culture positives out of which 10 (76.9%) were Gram negative pathogens and 3 (23%) were Gram positive pathogens and 3/10 (30%) Gram negative pathogens were Multidrug resistant organisms (MDROs). CONCLUSION: It was observed that longer duration of catheter in situ was an important risk factor for EVD-related infections (ERIs) and also higher frequency of CSF sampling. A proper EVD infection prevention and control protocol must be followed in the form of a checklist at the time of EVD insertion. Tehran University of Medical Sciences 2022-04 /pmc/articles/PMC9168257/ /pubmed/35765554 http://dx.doi.org/10.18502/ijm.v14i2.9183 Text en Copyright © 2022 The Authors. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Mehreen, Syeda Fakiha
Padmaja, Kanne
Sudhaharan, Sukanya
Teja, Vijay D
Saradhi, Mudumba Vijay
Krishna, Y. Vamsi
Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title_full Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title_fullStr Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title_full_unstemmed Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title_short Clinical and microbiological spectrum of external ventricular drain related infections (EVDRIs) from a tertiary care center
title_sort clinical and microbiological spectrum of external ventricular drain related infections (evdris) from a tertiary care center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168257/
https://www.ncbi.nlm.nih.gov/pubmed/35765554
http://dx.doi.org/10.18502/ijm.v14i2.9183
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