Cargando…

Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers

Aminopeptidase N (APN, CD13) is closely associated with the development and progression of cancer. Previous studies suggested APN as a biomarker for cancer stem cells. APN inhibitors have been intensively evaluated as chemosensitizers for cancer treatments. In the present study, tetrahydro-β-carboli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xing, Xiaoyan, Li, Fahui, Hu, Yajie, Zhang, Lin, Hui, Qian, Qin, Hongyu, Jiang, Qixiao, Jiang, Wenyan, Fang, Chunyan, Zhang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168271/ https://www.ncbi.nlm.nih.gov/pubmed/35677165 http://dx.doi.org/10.3389/fonc.2022.894842

Ejemplares similares

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors
por: Abadi, Ashraf H., et al.
Publicado: (2011)

Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
por: Sokolova, Nadezhda V, et al.
Publicado: (2014)

Synthesis of tetrahydro-β-carbolines from 2-indolylmethyl azides and propargylic alcohols
por: Yin, Haiting, et al.
Publicado: (2021)

Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines
por: Jaromin, Anna, et al.
Publicado: (2021)

Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi
por: Buaban, Koonchira, et al.
Publicado: (2021)

Electrochemical oxidative rearrangement of tetrahydro-β-carbolines in a zero-gap flow cell
por: Zheng, Yiting, et al.
Publicado: (2022)

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction
por: Xu, Shi-Ming, et al.
Publicado: (2019)

Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro
por: Liang, Yan, et al.
Publicado: (2022)

Pharmacological Importance of Optically Active Tetrahydro-β-carbolines and Synthetic Approaches to Create the C1 Stereocenter
por: Laine, Aino E., et al.
Publicado: (2014)

Carbazole and tetrahydro-carboline derivatives as dopamine D(3) receptor antagonists with the multiple antipsychotic-like properties
por: Li, Zhongtang, et al.
Publicado: (2023)

Asymmetric Synthesis of (R)‐1‐Alkyl‐Substituted Tetrahydro‐ß‐carbolines Catalyzed by Strictosidine Synthases
por: Pressnitz, Desiree, et al.
Publicado: (2018)

Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4
por: Liang, Yan, et al.
Publicado: (2021)

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure
por: Airaghi, Francesco, et al.
Publicado: (2013)

Enzymatic Strategy for the Resolution of New 1‐Hydroxymethyl Tetrahydro‐β‐carboline Derivatives in Batch and Continuous‐Flow Systems
por: Megyesi, Rita, et al.
Publicado: (2016)

A facile and efficient method for the synthesis of crystalline tetrahydro-β-carbolines via the Pictet-Spengler reaction in water
por: Byeon, Hong-Ju, et al.
Publicado: (2020)

Diastereoselective approach to rationally design tetrahydro-β-carboline–isatin conjugates as potential SERMs against breast cancer
por: Sharma, Bharvi, et al.
Publicado: (2019)

TCCA-mediated oxidative rearrangement of tetrahydro-β-carbolines: facile access to spirooxindoles and the total synthesis of (±)-coerulescine and (±)-horsfiline
por: Sathish, Manda, et al.
Publicado: (2021)

Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N-(3-Hydroxyindole)-Appended β-Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer
por: Sharma, Bharvi, et al.
Publicado: (2020)

Oxidative Asymmetric Formal Aza-Diels–Alder Reactions of Tetrahydro-β-carboline with Enones in the Synthesis of Indoloquinolizidine-2-ones
por: Wu, Xiang, et al.
Publicado: (2018)

Ingenine F: A New Cytotoxic Tetrahydro Carboline Alkaloid from the Indonesian Marine Sponge Acanthostrongylophora ingens
por: Ibrahim, Sabrin, et al.
Publicado: (2018)

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors
por: Elhady, Ahmed K., et al.
Publicado: (2015)

cis-(9S,10S)-Methyl 1-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate
por: Alam, Samina, et al.
Publicado: (2008)

Alterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline
por: Sontag, Thomas A., et al.
Publicado: (2009)

Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors
por: Liang, Jingwei, et al.
Publicado: (2017)

Aza-Annulation of 1,2,3,4-Tetrahydro-β-carboline Derived Enaminones and Nitroenamines: Synthesis of Functionalized Indolizino[8,7-b]indoles, Pyrido[1,2-a:3,4-b′]diindoles, Indolo[2,3-a]quinolizidine-4-ones and Other Tetrahydro-β-carboline Fused Heterocycles
por: Avadhani, Anusha, et al.
Publicado: (2019)

Synthesis and in silico screening of a library of β-carboline-containing compounds
por: Brummond, Kay M, et al.
Publicado: (2012)

Discovery of Novel α-Carboline Inhibitors of the Anaplastic Lymphoma Kinase
por: Mologni, Luca, et al.
Publicado: (2022)

1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Induces the Apoptosis of Dopaminergic Neurons via Oxidative Stress and Neuroinflammation
por: Yang, Yihang, et al.
Publicado: (2019)

Synthesis of 1-Substituted Carbazolyl-1,2,3,4-tetrahydro- and Carbazolyl-3,4-dihydro-β-carboline Analogs as Potential Antitumor Agents
por: Shen, Ya-Ching, et al.
Publicado: (2011)

Basic studies on epigenetic carcinogenesis of low-dose exposure to 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) in vitro
por: Wang, Renjie, et al.
Publicado: (2017)

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy
por: Qin, Jiang-Jiang, et al.
Publicado: (2018)

(1)H and (13)C NMR Assignments of Cytotoxic 3S-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from the Leaves of Cichorium endivia
por: Wang, Fu-Xin, et al.
Publicado: (2012)

Correction to “Discovery of Novel α-Carboline Inhibitors of the Anaplastic Lymphoma Kinase”
por: Mologni, Luca, et al.
Publicado: (2022)

(3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from Cichorium endivia. L Induces Apoptosis of Human Colorectal Cancer HCT-8 Cells
por: Wang, Fu-Xin, et al.
Publicado: (2012)

β-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii
por: Li, Shi-Fei, et al.
Publicado: (2012)

Calcium-Binding Protein S100P Promotes Tumor Progression but Enhances Chemosensitivity in Breast Cancer
por: Cong, Yizi, et al.
Publicado: (2020)

Yeast-Hydrolysate-Derived 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic Acid Inhibits Fat Accumulation during Adipocyte Differentiation
por: Kim, Nari, et al.
Publicado: (2023)

Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers
por: Andersson, Hanna, et al.
Publicado: (2012)

Design and Synthesis of Fluorescent 1,3-Diaryl-β-carbolines and 1,3-Diaryl-3,4-dihydro-β-carbolines
por: Pu, JiYang, et al.
Publicado: (2021)

Evolution from Natural β-Carboline Alkaloids to Obtain 1,2,4,9-tetrahydro-3-thia-9-aza-fluorene Derivatives as Potent Fungicidal Agents against Rhizoctonia solani
por: Xi, Junmin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0gqcsg4n1ma6lstencaljjibli