Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies

Indoleamine 2,3-dioxygenase 1 (IDO1) plays a predominant role in cancer immunotherapy which catalyzes the initial and rate limiting steps of the kynurenine pathway as a key enzyme. To explore novel IDO1 inhibitors, five derivatives of erlotinib-linked 1,2,3-triazole compounds were designed by using...

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Detalles Bibliográficos
Autores principales: Xu, Gui-Qing, Gong, Xiao-Qing, Zhu, Ying-Ying, Yao, Xiao-Jun, Peng, Li-Zeng, Sun, Ge, Yang, Jian-Xue, Mao, Long-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168369/
https://www.ncbi.nlm.nih.gov/pubmed/35677437
http://dx.doi.org/10.3389/fphar.2022.854965

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