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Anti-Inflammatory Activities of Betulinic Acid: A Review
Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168372/ https://www.ncbi.nlm.nih.gov/pubmed/35677426 http://dx.doi.org/10.3389/fphar.2022.883857 |
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author | Oliveira-Costa, José Fernando Meira, Cássio Santana Neves, Maria Vitória Gomes das Dos Reis, Bruna Padilha Zurita Claro Soares, Milena Botelho Pereira |
author_facet | Oliveira-Costa, José Fernando Meira, Cássio Santana Neves, Maria Vitória Gomes das Dos Reis, Bruna Padilha Zurita Claro Soares, Milena Botelho Pereira |
author_sort | Oliveira-Costa, José Fernando |
collection | PubMed |
description | Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are associated with diverse side effects and risk of toxicity. Betulinic acid, a lupane-type pentacyclic triterpene, is a potential lead compound for the development of new anti-inflammatory treatments, and a large number of derivatives have been produced and tested. The potential of betulinic acid and its derivatives has been shown in a number of pre-clinical studies using different experimental models. Moreover, several molecular mechanisms of action have also been described. Here we reviewed the potential use of betulinic acid as a promissory lead compound with anti-inflammatory activity and the perspectives for its use in the treatment of inflammatory conditions. |
format | Online Article Text |
id | pubmed-9168372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91683722022-06-07 Anti-Inflammatory Activities of Betulinic Acid: A Review Oliveira-Costa, José Fernando Meira, Cássio Santana Neves, Maria Vitória Gomes das Dos Reis, Bruna Padilha Zurita Claro Soares, Milena Botelho Pereira Front Pharmacol Pharmacology Inflammatory diseases have a high prevalence and has become of great interest due to the increase in life expectancy and the costs to the health care system worldwide. Chronic diseases require long-term treatment frequently using corticosteroids and non-steroidal anti-inflammatory drugs, which are associated with diverse side effects and risk of toxicity. Betulinic acid, a lupane-type pentacyclic triterpene, is a potential lead compound for the development of new anti-inflammatory treatments, and a large number of derivatives have been produced and tested. The potential of betulinic acid and its derivatives has been shown in a number of pre-clinical studies using different experimental models. Moreover, several molecular mechanisms of action have also been described. Here we reviewed the potential use of betulinic acid as a promissory lead compound with anti-inflammatory activity and the perspectives for its use in the treatment of inflammatory conditions. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9168372/ /pubmed/35677426 http://dx.doi.org/10.3389/fphar.2022.883857 Text en Copyright © 2022 Oliveira-Costa, Meira, Neves, Dos Reis and Soares. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Oliveira-Costa, José Fernando Meira, Cássio Santana Neves, Maria Vitória Gomes das Dos Reis, Bruna Padilha Zurita Claro Soares, Milena Botelho Pereira Anti-Inflammatory Activities of Betulinic Acid: A Review |
title | Anti-Inflammatory Activities of Betulinic Acid: A Review |
title_full | Anti-Inflammatory Activities of Betulinic Acid: A Review |
title_fullStr | Anti-Inflammatory Activities of Betulinic Acid: A Review |
title_full_unstemmed | Anti-Inflammatory Activities of Betulinic Acid: A Review |
title_short | Anti-Inflammatory Activities of Betulinic Acid: A Review |
title_sort | anti-inflammatory activities of betulinic acid: a review |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168372/ https://www.ncbi.nlm.nih.gov/pubmed/35677426 http://dx.doi.org/10.3389/fphar.2022.883857 |
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