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Preparation and Characterization of Site-Specific Fatty Chain-Modified Recombinant Human Granulocyte Colony Stimulating Factor

The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was studied in mi...

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Detalles Bibliográficos
Autores principales:	Wang, Xu-Dong, Yu, Wei-Jia, Liu, Jia-Hui, Du, Jie, Chen, Kang-Nan, Hu, Qin-Qin, Sun, Wen-Long, Ying, Guo-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168434/ https://www.ncbi.nlm.nih.gov/pubmed/35677307 http://dx.doi.org/10.3389/fbioe.2022.923059

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