Cargando…

An affordable implantable vagus nerve stimulator system for use in animal research

In this research, a vagus nerve stimulator has been developed and miniaturized for use in epilepsy research. The board contains all the components necessary for its operation during the standard duration of the experiments, being possible to control it once implanted and even being able to reuse it....

Descripción completa

Detalles Bibliográficos
Autores principales: Canal-Alonso, Ángel, Casado-Vara, Roberto, Castellano, Orlando, Herrera-Santos, Jorge, Gonçalves, Jaime, Màrquez-Sànchez, Sergio, Gonçalves, Jesús María, Corchado, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168444/
https://www.ncbi.nlm.nih.gov/pubmed/35658680
http://dx.doi.org/10.1098/rsta.2021.0010
_version_ 1784721010598084608
author Canal-Alonso, Ángel
Casado-Vara, Roberto
Castellano, Orlando
Herrera-Santos, Jorge
Gonçalves, Jaime
Màrquez-Sànchez, Sergio
Gonçalves, Jesús María
Corchado, Juan Manuel
author_facet Canal-Alonso, Ángel
Casado-Vara, Roberto
Castellano, Orlando
Herrera-Santos, Jorge
Gonçalves, Jaime
Màrquez-Sànchez, Sergio
Gonçalves, Jesús María
Corchado, Juan Manuel
author_sort Canal-Alonso, Ángel
collection PubMed
description In this research, a vagus nerve stimulator has been developed and miniaturized for use in epilepsy research. The board contains all the components necessary for its operation during the standard duration of the experiments, being possible to control it once implanted and even being able to reuse it. The VNS system has been designed for rodents since the VNS devices available for human are not only too large for laboratory animals, but also too expensive. With this solution the expenditure on materials made by laboratories is greatly reduced and bioethical considerations were kept in mind. The system was validated in hamsters. This article is part of the theme issue ‘Advanced neurotechnologies: translating innovation for health and well-being’.
format Online
Article
Text
id pubmed-9168444
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-91684442022-06-12 An affordable implantable vagus nerve stimulator system for use in animal research Canal-Alonso, Ángel Casado-Vara, Roberto Castellano, Orlando Herrera-Santos, Jorge Gonçalves, Jaime Màrquez-Sànchez, Sergio Gonçalves, Jesús María Corchado, Juan Manuel Philos Trans A Math Phys Eng Sci Articles In this research, a vagus nerve stimulator has been developed and miniaturized for use in epilepsy research. The board contains all the components necessary for its operation during the standard duration of the experiments, being possible to control it once implanted and even being able to reuse it. The VNS system has been designed for rodents since the VNS devices available for human are not only too large for laboratory animals, but also too expensive. With this solution the expenditure on materials made by laboratories is greatly reduced and bioethical considerations were kept in mind. The system was validated in hamsters. This article is part of the theme issue ‘Advanced neurotechnologies: translating innovation for health and well-being’. The Royal Society 2022-07-25 2022-06-06 /pmc/articles/PMC9168444/ /pubmed/35658680 http://dx.doi.org/10.1098/rsta.2021.0010 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Canal-Alonso, Ángel
Casado-Vara, Roberto
Castellano, Orlando
Herrera-Santos, Jorge
Gonçalves, Jaime
Màrquez-Sànchez, Sergio
Gonçalves, Jesús María
Corchado, Juan Manuel
An affordable implantable vagus nerve stimulator system for use in animal research
title An affordable implantable vagus nerve stimulator system for use in animal research
title_full An affordable implantable vagus nerve stimulator system for use in animal research
title_fullStr An affordable implantable vagus nerve stimulator system for use in animal research
title_full_unstemmed An affordable implantable vagus nerve stimulator system for use in animal research
title_short An affordable implantable vagus nerve stimulator system for use in animal research
title_sort affordable implantable vagus nerve stimulator system for use in animal research
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168444/
https://www.ncbi.nlm.nih.gov/pubmed/35658680
http://dx.doi.org/10.1098/rsta.2021.0010
work_keys_str_mv AT canalalonsoangel anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT casadovararoberto anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT castellanoorlando anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT herrerasantosjorge anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT goncalvesjaime anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT marquezsanchezsergio anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT goncalvesjesusmaria anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT corchadojuanmanuel anaffordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT canalalonsoangel affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT casadovararoberto affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT castellanoorlando affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT herrerasantosjorge affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT goncalvesjaime affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT marquezsanchezsergio affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT goncalvesjesusmaria affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch
AT corchadojuanmanuel affordableimplantablevagusnervestimulatorsystemforuseinanimalresearch