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Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ―
Background: Although cardiac resynchronization therapy (CRT) is effective for patients with chronic heart failure (CHF) with reduced left ventricular ejection fraction and wide QRS (≥120 ms), data on the use of or long-term outcomes after CRT implantation in Japan are limited. Methods and Results: W...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Circulation Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168508/ https://www.ncbi.nlm.nih.gov/pubmed/35774073 http://dx.doi.org/10.1253/circrep.CR-22-0036 |
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author | Hayashi, Hideka Yasuda, Satoshi Nakano, Makoto Sakata, Yasuhiko Nochioka, Kotaro Shiroto, Takashi Hasebe, Yuhi Noda, Takashi Miyata, Satoshi Shimokawa, Hiroaki |
author_facet | Hayashi, Hideka Yasuda, Satoshi Nakano, Makoto Sakata, Yasuhiko Nochioka, Kotaro Shiroto, Takashi Hasebe, Yuhi Noda, Takashi Miyata, Satoshi Shimokawa, Hiroaki |
author_sort | Hayashi, Hideka |
collection | PubMed |
description | Background: Although cardiac resynchronization therapy (CRT) is effective for patients with chronic heart failure (CHF) with reduced left ventricular ejection fraction and wide QRS (≥120 ms), data on the use of or long-term outcomes after CRT implantation in Japan are limited. Methods and Results: We examined proper CRT utilization and outcomes in 3,447 consecutive symptomatic CHF patients registered in the CHART-2 Study. We identified 167 potentially eligible patients and divided them into 4 groups according to the presence (+) or absence (−) of an indication for and implantation of CRT: Group A (reference group), (+)indication/(+)CRT; Group B, (+)indication/(−)CRT; Group C, (−)indication/(+)CRT; and Group D, (−)indication/(−)CRT. Based on the Japanese Circulation Society guidelines, 91 patients met the eligibility for CRT implantation, with 43 (47%) of them undergoing CRT implantation. After adjusting for confounders, age was significantly associated with no CRT use (odds ratio per 5-year increase 1.46; 95% confidence interval 1.11–2.05; P=0.012). Among the 4 groups, the cumulative incidence of cardiovascular death and CHF admission were highest in Group B and lowest in Group D (P=0.029). Conclusions: In this study, only half the eligible CHF patients properly received CRT. Aging was a significant risk factor for no CRT use. Patients without CRT despite having an indication could be at higher risk of mortality and CHF admission. |
format | Online Article Text |
id | pubmed-9168508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Circulation Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91685082022-06-29 Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― Hayashi, Hideka Yasuda, Satoshi Nakano, Makoto Sakata, Yasuhiko Nochioka, Kotaro Shiroto, Takashi Hasebe, Yuhi Noda, Takashi Miyata, Satoshi Shimokawa, Hiroaki Circ Rep Original article Background: Although cardiac resynchronization therapy (CRT) is effective for patients with chronic heart failure (CHF) with reduced left ventricular ejection fraction and wide QRS (≥120 ms), data on the use of or long-term outcomes after CRT implantation in Japan are limited. Methods and Results: We examined proper CRT utilization and outcomes in 3,447 consecutive symptomatic CHF patients registered in the CHART-2 Study. We identified 167 potentially eligible patients and divided them into 4 groups according to the presence (+) or absence (−) of an indication for and implantation of CRT: Group A (reference group), (+)indication/(+)CRT; Group B, (+)indication/(−)CRT; Group C, (−)indication/(+)CRT; and Group D, (−)indication/(−)CRT. Based on the Japanese Circulation Society guidelines, 91 patients met the eligibility for CRT implantation, with 43 (47%) of them undergoing CRT implantation. After adjusting for confounders, age was significantly associated with no CRT use (odds ratio per 5-year increase 1.46; 95% confidence interval 1.11–2.05; P=0.012). Among the 4 groups, the cumulative incidence of cardiovascular death and CHF admission were highest in Group B and lowest in Group D (P=0.029). Conclusions: In this study, only half the eligible CHF patients properly received CRT. Aging was a significant risk factor for no CRT use. Patients without CRT despite having an indication could be at higher risk of mortality and CHF admission. The Japanese Circulation Society 2022-05-25 /pmc/articles/PMC9168508/ /pubmed/35774073 http://dx.doi.org/10.1253/circrep.CR-22-0036 Text en Copyright © 2022, THE JAPANESE CIRCULATION SOCIETY https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. |
spellingShingle | Original article Hayashi, Hideka Yasuda, Satoshi Nakano, Makoto Sakata, Yasuhiko Nochioka, Kotaro Shiroto, Takashi Hasebe, Yuhi Noda, Takashi Miyata, Satoshi Shimokawa, Hiroaki Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title | Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title_full | Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title_fullStr | Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title_full_unstemmed | Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title_short | Utilization and Efficacy of Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure ― A Report From the CHART-2 Study ― |
title_sort | utilization and efficacy of cardiac resynchronization therapy in patients with chronic heart failure ― a report from the chart-2 study ― |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168508/ https://www.ncbi.nlm.nih.gov/pubmed/35774073 http://dx.doi.org/10.1253/circrep.CR-22-0036 |
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